PDF(Pubmed)
Abstract：
Notably, the growing use of radionuclear technology, especially in diagnostic and therapeutic procedures involving radiation exposure, raises concerns about the health effects of radiation. Although epidemiological studies have provided strong evidence for elevated thyroid cancer risk after radiation exposure in childhood, the risk of thyroid cancer associated with adult exposure remains to be investigated. We conducted a systematic review and meta-analysis of relevant studies on the risk of developing thyroid cancer after radiation exposure in adulthood. The PubMed and Web of Science databases were used to select eligible articles. After screening, a total of 15 studies were identified in which estimates of the standardized incidence ratio (SIR) and the relative risk (RR) of thyroid cancer were available in 8 and 11 studies, respectively. The overall SIR estimated by the random effects model was 2.19 [95% confidence interval (CI), 1.54, 3.10]. Cochran\'s Q test showed significant heterogeneity in the SIRs (Q = 178, P < 0.0001). The overall RR at 10 mGy was 1.0038 (95% CI, 0.9991, 1.0085), with no significant heterogeneity (Q = 9.30, P = 0.5041). The total SIR, as well as that from each study, indicated a statistically significant excess, which could be related to screening bias. Radiation-related thyroid cancer risk was elevated in a few studies; however, the overall estimate of the RR at 10 mGy was not significant. This study demonstrates no strong epidemiological evidence for the risk of thyroid cancer in radiation exposure during adulthood; however, further research is needed.
摘要：
值得注意的是,越来越多地使用放射性核技术，特别是在涉及辐射暴露的诊断和治疗程序中，引起人们对辐射对健康影响的担忧。尽管流行病学研究提供了强有力的证据，表明儿童接受辐射后患甲状腺癌的风险升高，与成人接触相关的甲状腺癌风险仍有待研究.我们对成年期辐射暴露后患甲状腺癌风险的相关研究进行了系统评价和荟萃分析。PubMed和WebofScience数据库用于选择符合条件的文章。筛选后,共确定了15项研究，其中有8项和11项研究估计了甲状腺癌的标准化发病率（SIR）和相对风险（RR）。分别。随机效应模型估计的总体SIR为2.19[95%置信区间(CI)，1.54、3.10]。Cochran的Q检验显示SIR具有显著的异质性(Q=178,P<0.0001)。10mGy时的总RR为1.0038(95%CI，0.9991，1.0085)，差异无统计学意义(Q=9.30,P=0.5041)。总SIR,以及每一项研究，表明有统计学意义的超额，这可能与筛查偏倚有关。在一些研究中，辐射相关的甲状腺癌风险升高；然而，RR在10mGy时的总体估计值不显著.这项研究表明，没有强有力的流行病学证据表明，在成年期辐射暴露中甲状腺癌的风险；然而，需要进一步的研究。
