{Reference Type}: Journal Article {Title}: Advanced Interventional Treatments in Retinoblastoma Management: A Comprehensive Review. {Author}: Kolyvas P;Mir A;Stirrat T;Brookner B;Pilar N;Monroe E;Ahuja R; {Journal}: Cardiovasc Intervent Radiol {Volume}: 47 {Issue}: 4 {Year}: 2024 Apr 20 {Factor}: 2.797 {DOI}: 10.1007/s00270-024-03692-2 {Abstract}: Retinoblastoma is the most common eye malignancy in children that if left untreated can invade intraocular structures, metastasize, and rarely lead to death. Traditionally treated with systemic chemotherapy, Intra-arterial chemotherapy is gaining popularity as it allows for the direct administration of chemotherapy through the ophthalmic artery, thus reducing systemic side effects. Intra-arterial chemotherapy procedures have evolved, with refinements to reduce risks and radiation exposure. Intra-arterial chemotherapy boasts an impressive technical success rate and one year ocular survival even amongst advanced cases. This review offers a thorough examination of the technique, indications, contraindications, outcomes, and alternative options for Intra-arterial chemotherapy.