背景:木质素由于无毒而引起了很多关注,可再生和可生物降解。木质素纳米颗粒(LNP)具有高的比表面积和比表面电荷。它为LNP提供了良好的抗菌和抗氧化性能。LNP准备工作已经变得清晰,然而,申请仍处于早期阶段。
目的:进行了以综述为中心的研究,回顾现有文献,以完成对LNP医疗应用的基本理解。
方法:最初,我们广泛地建议从各种来源的木质素的异质性。然后讨论了来自不同制备工艺的LNPs的尺寸和形态。随后,我们专注于LNP的潜在医学应用,包括药物输送,伤口愈合,组织工程,和抗菌剂。最后,我们解释了LNP在抗菌方面的重要性,抗氧化剂和生物相容性,特别强调需要一个综合框架来理解LNP的各种医疗应用。
结果:我们概述了不同类型木质素的化学结构,并重点介绍了木质素纳米颗粒的先进制备方法。此外,我们对木质素纳米颗粒在各种医学领域的潜在应用进行了深入的综述,特别是在药物携带者中,伤口敷料,组织工程组件,和抗菌剂。
结论:这篇综述详细概述了用于医学应用的木质素纳米颗粒的现状和进展。
BACKGROUND: Lignin has attracted a lot of attention because it is non-toxic, renewable and biodegradable. Lignin nanoparticles (LNPs) have high specific surface area and specific surface charges. It provides LNPs with good antibacterial and antioxidant properties. LNPs preparation has become clear, however, the application remains in the early stages.
OBJECTIVE: A
review centric research has been conducted, reviewing existing literature to accomplish a basic understanding of the medical applications of LNPs.
METHODS: Initially, we extensively counseled the heterogeneity of lignin from various sources. The size and morphology of LNPs from different preparation process were then discussed. Subsequently, we focused on the potential medical applications of LNPs, including drug delivery, wound healing, tissue engineering, and antibacterial agents. Lastly, we explained the significance of LNPs in terms of antibacterial, antioxidant and biocompatibility, especially highlighting the need for an integrated framework to understand a diverse range of medical applications of LNPs.
RESULTS: We outlined the chemical structure of different type of lignin, and highlighted the advanced methods for lignin nanoparticles preparation. Moreover, we provided an in-depth
review of the potential applications of lignin nanoparticles in various medical fields, especially in drug carriers, wound dressings, tissue engineering components, and antimicrobial agents.
CONCLUSIONS: This
review provides a detailed overview on the current state and progression of lignin nanoparticles for medical applications.