Abstract：
The skin, serving as the body\'s outermost layer, boasts a vast area and intricate structure, functioning as the primary barrier against external threats. Disruptions in the composition and functionality of the skin can lead to a diverse array of skin conditions, such as wounds, burns, and diabetic ulcers, along with inflammatory disorders, infections, and various types of skin cancer. These disorders not only exacerbate concerns regarding skin health and beauty but also have a significant impact on mental well-being. Due to the complexity of these disorders, conventional treatments often prove insufficient, necessitating the exploration of new therapeutic approaches. Researchers develop new therapies by deciphering these intricacies and gaining a thorough understanding of the protein networks and molecular processes in skin. A new window of opportunity has opened up for improving wound healing processes because of recent advancements in skin gene therapy. To enhance skin regeneration and healing, this extensive review investigates the use of novel dressing scaffolds in conjunction with gene therapy approaches. Scaffolds that do double duty as wound protectors and vectors for therapeutic gene delivery are being developed using innovative biomaterials. To improve cellular responses and speed healing, these state-of-the-art scaffolds allow for the targeted delivery and sustained release of genetic material. The most recent developments in gene therapy techniques include RNA interference, CRISPR-based gene editing, and the utilization of viral and non-viral vectors in conjunction with scaffolds, which were reviewed here to overcome skin disorders and wound complications. In the future, there will be rare chances to develop custom methods for skin health care thanks to the combination of modern technology and collaboration among disciplines.
摘要：
皮肤，作为身体的最外层，拥有广阔的区域和复杂的结构，作为抵御外部威胁的主要屏障。皮肤的组成和功能的破坏会导致各种各样的皮肤状况，比如伤口，烧伤,和糖尿病性溃疡，伴随着炎症性疾病，感染,和各种类型的皮肤癌。这些疾病不仅加剧了对皮肤健康和美丽的担忧，而且对心理健康有重大影响。由于这些疾病的复杂性，常规治疗往往被证明是不够的，有必要探索新的治疗方法。研究人员通过破译这些复杂性并深入了解皮肤中的蛋白质网络和分子过程来开发新的疗法。由于皮肤基因疗法的最新进展，为改善伤口愈合过程开辟了新的机会之窗。增强皮肤再生和愈合，这篇广泛的综述研究了新型敷料支架与基因治疗方法的结合使用。正在使用创新的生物材料开发作为伤口保护剂和用于治疗性基因递送的载体的双重作用的支架。为了改善细胞反应和加速愈合，这些最先进的支架允许靶向递送和持续释放遗传物质。基因治疗技术的最新进展包括RNA干扰，基于CRISPR的基因编辑，以及将病毒和非病毒载体与支架结合使用，本文对克服皮肤病和伤口并发症的方法进行了综述。在未来,由于现代技术和学科之间的合作相结合，将很少有机会开发定制的皮肤保健方法。
