干燥的 L - 色氨酸发酵产物在 Sprague - Dawley 大鼠中的安全性评价。
关键词: BUN, blood urea nitrogen DRF, dose range-finding Dried L-tryptophan fermentation product EMS, eosinophilia-myalgia syndrome Eosinophilia-myalgia syndrome FFPE, formalin-fixed paraffin-embedded GHS, globally harmonized system GLP, good laboratory practice HED, human equivalent dose IHC, immunohistochemistry Metabolically engineered Corynebacterium glutamicum NOAEL, no observed adverse effect level OECD, Organization for Economic Cooperation and Development Oral administration SD, Sprague-Dawley Subchronic toxicity WBC, white blood cell pAb, polyclonal antibody
来 源:
DOI:10.1016/j.toxrep.2022.05.005
PDF(Pubmed)