bartogenicacid(BA),一种活性五环三萜类化合物,已经被报道用于抗糖尿病,抗炎,抗关节炎,抗癌,和抗肿瘤活性。然而,到目前为止,BA的毒性分析尚未报道。因此,本研究旨在评估BA单剂量(12.5,25,50和100mg/kg)和重复剂量(1.5,6和24mg/kg)对BALB/c小鼠的静脉毒性.对照组接受车辆。在单剂量毒性研究中,在100mg/kgBA时观察到两次死亡,而较低剂量的患者耐受性良好。在重复剂量毒性研究中,没有观察到死亡。1.5mg/kg的BA在两种性别的小鼠中均有良好的耐受性。在6mg/kg的BA,与对照组相比,雌性小鼠的体重显着降低,但在雄性小鼠中没有观察到明显的变化。24mg/kg的BA显示两种性别的小鼠的体重显著降低。Further,这些小鼠显示出相对器官重量的显著变化。然而,在血液学中没有观察到毒理学相关的变化,生物化学,和组织病理学。根据调查结果,发现BA的未观察到的不良反应水平(NOAEL)对于雄性小鼠为<24mg/kg,对于雌性小鼠为<6mg/kg。
Bartogenic acid (BA), an active pentacyclic triterpenoid, has been reported for anti-diabetic, anti-inflammatory, anti-arthritic, anti-cancer, and anti-tumor activity. However, toxicity profiling of BA has not been reported till date. Hence, this study is designed to evaluate the single dose (12.5, 25, 50 and 100 mg/kg) and repeated dose (1.5, 6, and 24 mg/kg) intravenous toxicity of BA in BALB/c mice. Control group received vehicle. In single dose toxicity study, two mortalities were observed at 100 mg/kg of BA whereas lower doses were well tolerated. In repeated dose toxicity study, no mortality was observed. 1.5 mg/kg of BA was well tolerated in mice of both sexes. At 6 mg/kg of BA, female mice showed significant reduction in the body weight as compared to the control group however no significant change was observed in male mice. 24 mg/kg of BA showed significant reduction in the body weight in mice of both sexes. Further, these mice showed significant change in the relative organ weight. However, no toxicologically relevant changes were observed in hematology, biochemistry, and histopathology. Based on the findings, No-Observed-Adverse-Effect-Level (NOAEL) for BA were found to be<24 mg/kg for male mice and<6 mg/kg for female mice.