未经证实:磨砂斑疹伤寒(ST)是一种由立克次体家族的专性细胞内细菌引起的急性发热性疾病。它通常未被识别和忽视,但在流行地区的热带地区普遍存在。这种诊断困境背后的悲剧是非特异性的临床体征和症状,意识有限,诊断设施不可用,医生的怀疑指数低。为了解决知识差距,我们试图找出一个合适的实验室调查小组来诊断该疾病并预测其进展,因为在尼泊尔西部的一家三级医院中,该疾病的病程不确定.
UNASSIGNED:这是一项基于医院实验室的前瞻性研究,在甘达基医学院教学医院(GMC-TH)进行了为期两年的研究。在988例急性高热性疾病中,研究中纳入了40例ST血清阳性病例。我们排除了那些不同意参加的人,那些17岁以下的人,以及先前存在肝功能障碍和其他共病以及与其他感染病因双重血清阳性的患者。我们使用描述性统计数据从人口统计学的角度分析数据,临床特征,和实验室参数。
未经证实:在988名发热患者中,在研究期间,我们纳入了40例确诊的ST患者,年龄在17~70岁之间.最大的血清阳性病例来自Tanahun区14(35%),以女性为主(70%)。这些病例流行于30-60岁年龄组,19(47.5%),10月15日(37.5%)。最常见的投诉是40人发烧(100%),头痛在20(50%),焦11(27.5%)。实验室参数显示贫血22(55%),低白蛋白血症11例(27.5%),白细胞减少5例(12.5%),9(22.5%)的白细胞增多,13例血小板减少症(32.5%),提高转氨酶水平,21例(52.5%)的SGPT和14例(26%)的SGOT。
未经证实:我们发现ST患者的临床和实验室特征是不同的和非特异性的。然而,对这些发现的了解可能会唤起对ST的认识,并为疾病的进展提供线索.
UNASSIGNED: Scrub Typhus (ST) is an acute febrile illness caused by obligate intracellular bacteria of the family Rickettsia. It is often unrecognized and neglected but prevalent in tropical regions of endemic areas. The tragedy behind this diagnostic dilemma is non-specific clinical signs and symptoms, limited awareness, unavailability of diagnostic facilities, and low index of suspicion among the physicians. To address the knowledge gap, we tried to find out a proper panel of laboratory investigations to diagnose the disease and predict its progression because of the uncertainty of the course of the disease in a tertiary care hospital in western Nepal.
UNASSIGNED: This is a hospital laboratory-based prospective study conducted at Gandaki Medical College- Teaching Hospital (GMC-TH) for a period of two years. Among 988 cases of acute febrile illness, 40 seropositive cases of ST were enrolled in the study. We excluded those who did not give consent for the participation, those who were under 17 years of age, and those who had preexisting liver dysfunctions and other co-morbidities and dual seropositive with other infectious etiologies. We used descriptive statistics to analyze the data in terms of demography, clinical features, and laboratory parameters.
UNASSIGNED: Out of 988 febrile patients, we included 40 confirmed cases of ST aged between 17 and 70 years during the study-period. Maximum seropositive cases were from Tanahun district 14 (35%), with predominance among the women (70%). The cases were prevalent in the age group 30-60 years, 19 (47.5%), and in the month of October 15 (37.5%). The commonest complaints were fever in 40 (100%), headache in 20 (50%), eschar in 11 (27.5%). Laboratory parameters showed anemia in 22 (55%), hypoalbuminemia in 11 (27.5%), leukopenia in 5 (12.5%), leukocytosis in 9 (22.5%), thrombocytopenia in 13 (32.5%), raised transaminase levels, SGPT in 21 (52.5%) and SGOT in 14 (26%) ST patients.
UNASSIGNED: We found clinical and laboratory profiles in patients with ST were varied and nonspecific. However, knowledge of these findings may evoke the recognition of ST and give a clue to the progression of the disease.