高尿酸血症通过抑制多药耐药蛋白 4 (MRP4) 和乳腺癌耐药蛋白 (BCRP) 影响色氨酸代谢。
关键词: AHR ANOVA BCRP CKD Ct E(1)S EDX EM FVB Gapdh HE stain HEK293 cells Hyperuricemia IC(50) IDO Kim-1 Kynurenic acid LC–MS/MS MRP4 MTX Ngal OAT Oxonic acid SEM SLC SNP URAT1 analysis of variance aryl hydrocarbon receptor breast cancer resistance protein chronic kidney disease cycle threshold eYFP electron microscopy energy-dispersive X-ray enhanced yellow fluorescent protein estrone sulphate friend leukemia virus B glyceraldehyde-3-phosphate dehydrogenase half maximal inhibitory concentration hematoxylin and eosin stain human embryonic kidney cells indoleamine 2,3-dioxygenase kidney injury molecule-1 liquid chromatography-tandem mass spectrometry methotrexate multidrug resistance protein 4 neutrophil gelatinase-associated lipocalin organic anion transporter single nucleotide polymorphism solute carrier family standard error of mean urate transporter 1
Mesh : ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Transporters / antagonists & inhibitors Acute-Phase Proteins / metabolism Biological Transport HEK293 Cells Humans Hyperuricemia / chemically induced metabolism Kynurenic Acid / metabolism Lipocalin-2 Lipocalins / metabolism Multidrug Resistance-Associated Proteins / antagonists & inhibitors Neoplasm Proteins / antagonists & inhibitors Oxonic Acid / administration & dosage Proto-Oncogene Proteins / metabolism Tryptophan / metabolism Uric Acid / metabolism
来 源:
DOI:10.1016/j.bbadis.2013.05.002
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