伤口愈合是一个复杂的生理过程,涉及止血,炎症,扩散,和组织重塑。因此,迫切需要合适的伤口敷料用于有效和系统的伤口管理。基于多肽的水凝胶生物粘合剂提供独特的优点并且是理想的候选物。然而,目前还缺乏对多肽类水凝胶生物粘合剂在伤口愈合方面的综合评价。在这次审查中,首先详细描述了伤口愈合的生理机制和评价参数。然后,总结了水凝胶生物粘合剂的工作原理。涉及明胶的多功能多肽基水凝胶生物粘合剂的最新进展,丝素蛋白,纤维蛋白,角蛋白,聚-γ-谷氨酸,炭黑-聚赖氨酸,血清白蛋白,综述了弹性蛋白在伤口愈合和组织修复中的促愈合活性。最后,当前状态,挑战,事态发展,并讨论了多肽类水凝胶生物粘合剂的未来发展趋势,希望进一步的发展将得到刺激,以满足其临床应用日益增长的需求。
Wound healing is a complex physiological process involving hemostasis, inflammation, proliferation, and tissue remodeling. Therefore, there is an urgent need for suitable wound dressings for effective and systematical wound management.
Polypeptide-based hydrogel bio-adhesives offer unique advantages and are ideal candidates. However, comprehensive reviews on
polypeptide-based hydrogel bio-adhesives for wound healing are still lacking. In this review, the physiological mechanisms and evaluation parameters of wound healing were first described in detail. Then, the working principles of hydrogel bio-adhesives were summarized. Recent advances made in multifunctional
polypeptide-based hydrogel bio-adhesives involving gelatin, silk fibroin, fibrin, keratin, poly-γ-glutamic acid, ɛ-poly-lysine, serum albumin, and elastin with pro-healing activities in wound healing and tissue repair were reviewed. Finally, the current status, challenges, developments, and future trends of
polypeptide-based hydrogel bio-adhesives were discussed, hoping that further developments would be stimulated to meet the growing needs of their clinical applications.