{Reference Type}: Journal Article
{Title}: Polypeptide- and Protein-Based Conjugate Nanoparticles via Aqueous Ring-Opening Polymerization-Induced Self-Assembly (ROPISA).
{Author}: Beauseroy H;Grazon C;Antoine S;Badreldin M;Salas-Ambrosio P;Harrisson S;Garanger E;Lecommandoux S;Bonduelle C;
{Journal}: Macromol Rapid Commun
{Volume}: 45
{Issue}: 14
{Year}: 2024 Jul 25
{Factor}: 5.006
{DOI}: 10.1002/marc.202400079
{Abstract}: Protein-polymer conjugates and polymeric nanomaterials hold great promise in many applications including biomaterials, medicine, or nanoelectronics. In this work, the first polymerization-induced self-assembly (PISA) approach performed in aqueous medium enabling protein-polymer conjugates and nanoparticles entirely composed of amino acids is presented by using ring-opening polymerization (ROP). It is indeed shown that aqueous ring-opening polymerization-induced self-assembly (ROPISA) can be used with protein or peptidic macroinitiators without prior chemical modification and afford the simple preparation of nanomaterials with protein-like property, for example, to implement biomimetic thermoresponsivity in drug delivery.