Abstract：
Protein-polymer conjugates and polymeric nanomaterials hold great promise in many applications including biomaterials, medicine, or nanoelectronics. In this work, the first polymerization-induced self-assembly (PISA) approach performed in aqueous medium enabling protein-polymer conjugates and nanoparticles entirely composed of amino acids is presented by using ring-opening polymerization (ROP). It is indeed shown that aqueous ring-opening polymerization-induced self-assembly (ROPISA) can be used with protein or peptidic macroinitiators without prior chemical modification and afford the simple preparation of nanomaterials with protein-like property, for example, to implement biomimetic thermoresponsivity in drug delivery.
摘要：
蛋白质-聚合物缀合物和聚合物纳米材料在许多应用中具有巨大的前景，包括生物材料，医学或纳米电子学。在这项工作中,我们提出了第一种在水性介质中进行的PISA（聚合诱导的自组装）方法，通过使用开环聚合（ROP）实现蛋白质-聚合物缀合物和完全由氨基酸组成的纳米颗粒。我们确实表明，水性ROPISA可以与蛋白质或肽大分子引发剂一起使用，而无需事先进行化学修饰，并且可以简单地制备具有蛋白质样性质的纳米材料，例如在药物递送中实现仿生热响应性。本文受版权保护。保留所有权利。
