%0 Journal Article
%T Polypeptide- and Protein-Based Conjugate Nanoparticles via Aqueous Ring-Opening Polymerization-Induced Self-Assembly (ROPISA).
%A Beauseroy H
%A Grazon C
%A Antoine S
%A Badreldin M
%A Salas-Ambrosio P
%A Harrisson S
%A Garanger E
%A Lecommandoux S
%A Bonduelle C
%J Macromol Rapid Commun
%V 45
%N 14
%D 2024 Jul 25
%M 38662380
%F 5.006
%R 10.1002/marc.202400079
%X Protein-polymer conjugates and polymeric nanomaterials hold great promise in many applications including biomaterials, medicine, or nanoelectronics. In this work, the first polymerization-induced self-assembly (PISA) approach performed in aqueous medium enabling protein-polymer conjugates and nanoparticles entirely composed of amino acids is presented by using ring-opening polymerization (ROP). It is indeed shown that aqueous ring-opening polymerization-induced self-assembly (ROPISA) can be used with protein or peptidic macroinitiators without prior chemical modification and afford the simple preparation of nanomaterials with protein-like property, for example, to implement biomimetic thermoresponsivity in drug delivery.