目的:神经传导研究(NCSs)被广泛用于支持神经肌肉疾病的临床诊断。这项研究的目的是获得腓骨的参考值,胫骨,和统计NCSs,并检查与人口统计学和人体测量学因素的关系。
方法:在马斯特里赫特研究的5099名没有2型糖尿病的参与者(年龄40-79岁)中,腓骨的NCS,胫骨,并进行了腓肠神经检查。复合肌肉动作电位(CMAP)和感觉神经动作电位振幅值,神经传导速度(NCV),并获得远端潜伏期。年龄的关联,性别,体重指数(BMI),使用一元和多元线性回归分析确定具有NCS值的身高。
结果:男性和女性每十年报告详细的参考值。在老年和高个子个体以及男性的所有神经中观察到显着较低的NCV和较长的远端潜伏期。在这些群体中,胫骨和腓肠神经的振幅明显较低,而腓骨下神经CMAP仅与年龄显着相关。BMI呈多方向关联。在多变量分析中校正人体测量因素后,性别和NCS值之间的关联不太直接.
结论:来自基于人群的数据集的这些值可以用作生成标准值的参考。我们的发现表明NCS值与人体测量因素之间存在关联。在临床实践中,解释NCS值时可以考虑这些因素。
OBJECTIVE: Nerve conduction studies (NCSs) are widely used to support the clinical diagnosis of neuromuscular disorders. The aims of this study were to obtain reference values for peroneal, tibial, and sural NCSs and to examine the associations with demographic and anthropometric factors.
METHODS: In 5099 participants (aged 40-79 years) without type 2 diabetes of The Maastricht Study, NCSs of peroneal, tibial, and sural nerves were performed. Values for compound muscle action potential (CMAP) and sensory nerve action potential amplitude, nerve conduction velocity (NCV), and distal latency were acquired. The association of age, sex, body mass index (BMI), and height with NCS values was determined using uni- and multivariate linear regression analyses.
RESULTS: Detailed reference values are reported per decade for men and women. Significantly lower NCVs and longer distal latencies were observed in all nerves in older and taller individuals as well as in men. In these groups, amplitudes of the tibial and sural nerves were significantly lower, whereas a lower peroneal nerve CMAP was only significantly associated with age. BMI showed a multidirectional association. After correction for anthropometric factors in the multivariate analysis, the association between sex and NCS values was less straightforward.
CONCLUSIONS: These values from a population-based dataset could be used as a reference for generating normative values. Our findings show the association of NCS values with anthropometric factors. In clinical practice, these factors can be considered when interpreting NCS values.