神经传导研究（NCS）对于评估免疫介导的神经炎研究模型中的周围神经纤维功能至关重要。然而,目前缺乏标准方案和参考值,这阻碍了模型和研究之间的数据可比性.我们对Lewis大鼠免疫介导性神经炎的近30年NCS进行了系统评价和随后的荟萃分析。26篇论文符合荟萃分析的纳入标准。提取的数据显示，记录的神经传导速度（NCV）和复合肌肉动作电位（CMAP）具有相当大的异质性。研究在技术方面也有很大的不同，有条不紊,和数据报告问题。基础研究的异质性强调在进行和报告大鼠NCS时需要标准化。我们提供了Lewis大鼠坐骨神经NCS的标准值，并提出了在研究Lewis大鼠的免疫范例时进行NCS时应解决的七个项目。
Nerve conduction studies (NCS) are essential to assess peripheral nerve fiber function in research models of immune-mediated neuritis. However, the current lack of standard protocols and reference values impedes data comparability across models and studies. We performed a systematic review and subsequent meta-analysis of the last 30 years of NCS of immune-mediated neuritis in Lewis-rats. Twenty-six papers met the inclusion criteria for meta-analysis. Extracted data showed considerable heterogeneity of recorded nerve conduction velocity (NCV) and compound muscle action potential (CMAP). Studies also significantly differed in terms of technical, methodical, and data reporting issues. The heterogeneity of the underlying studies emphasizes the need for standardization when conducting and reporting NCS in rats. We provide normative values for NCS of the sciatic nerve of Lewis rats and propose seven items that should be addressed when NCS are performed when studying immune paradigms in Lewis rats.
