创伤可导致周围神经损伤(PNI),手术切除,医源性损伤,和/或局部麻醉剂毒性。周围神经损伤可能导致虚弱无力,麻木,感觉异常,疼痛,和/或自主神经不稳定。由于PNI与炎症和神经变性有关,减轻这种反应的方法可能会导致结果的改善。已经研究了许多营养素来防止PNI的负面后遗症。α-硫辛酸,胞苷二磷酸胆碱(CDP胆碱),姜黄素,褪黑激素,在动物模型中,维生素B12和维生素E在改善PNI后的恢复方面取得了显著成功。虽然动物研究表明有充分的证据表明各种补充剂可以改善PNI后的恢复,人类患者的类似证据是有限的。本综述的目的是分析已成功用于PNI动物模型的补充剂,以作为未来人类患者研究的参考。通过分析在动物研究中显示出功效的补充剂,医疗保健提供者将有一个资源来指导有关未来人类研究的决策,这些研究调查补充剂在PNI恢复中可能发挥的作用.最终,在PNI后的人类患者中建立对这些补充剂的全面了解可能会显着改善手术后的结果,生活质量,和周围神经再生。
Peripheral nerve injury (PNI) can result from trauma, surgical resection, iatrogenic injury, and/or local anesthetic toxicity. Damage to peripheral nerves may result in debilitating weakness, numbness, paresthesia, pain, and/or autonomic instability. As PNI is associated with inflammation and nerve degeneration, means to mitigate this response could result in improved outcomes. Numerous nutrients have been investigated to prevent the negative sequelae of PNI. Alpha-lipoic acid, cytidine diphosphate-choline (CDP Choline), curcumin, melatonin, vitamin B12, and vitamin E have demonstrated notable success in improving recovery following PNI within animal models. While animal studies show ample evidence that various supplements may improve recovery after PNI, similar evidence in human patients is limited. The goal of this
review is to analyze supplements that have been used successfully in animal models of PNI to serve as a reference for future studies on human patients. By analyzing supplements that have shown efficacy in animal studies, healthcare providers will have a resource from which to guide decision-making regarding future human studies investigating the role that supplements could play in PNI recovery. Ultimately, establishing a comprehensive understanding of these supplements in human patients following PNI may significantly improve post-surgical outcomes, quality of life, and peripheral nerve regeneration.