背景:人类工作和生活中严重大流行的主观征兆是数学上的神经耳鸣。fNIRS(功能近红外光谱)是一种新的非侵入性脑成像技术,用于研究人类大脑皮层的神经活动。它基于神经耦合效应。这项研究使用fNIRS方法来检测声音刺激任务中脑皮肤神经活动的差异,以便更好地区分感觉性神经性耳鸣。
方法:在fNIRS脑成像方法中,14名感觉神经性耳鸣患者和14名健康对照者听了各种噪声和安静的fNIRS数据收集。在MATLAB中采用线性拟合来消除预处理和事件相关设计分析过程中的缓慢漂移。在IBMSPSSStatistics26.0中应用了错误发现率(FDR)程序,以控制多个比较分析中的假阳性率。
结果:当疾病组和健康对照组受到粉红噪声刺激时,血氧浓度差异有统计学意义(P<0.05),健康对照组表现出高度激活,根据fNIRS测量数据。在相同的刺激任务设置下,患者组的血氧浓度水平在针灸治疗一个月后显著提高,它与THI和TEQ量表的水平密切相关。
结论:以感觉神经性耳鸣疾病为例,fNIRS技术有可能在整个时间内揭示未来对主观疾病的病理研究。还可以检查涉及颞叶和邻近大脑区域的其他临床疾病。除了与耳鸣有关的大脑改变.
BACKGROUND: The subjective sign of a serious pandemic in human work and life is mathematical neural tinnitus. fNIRS (functional near-infrared spectroscopy) is a new non-invasive brain imaging technology for studying the neurological activity of the human cerebral cortex. It is based on neural coupling effects. This research uses the fNIRS approach to detect differences in the neurological activity of the cerebral skin in the sound stimulation mission in order to better discriminate between the sensational neurological tinnitus.
METHODS: In the fNIRS brain imaging method, 14 sensorineural tinnitus sufferers and 14 healthy controls listened to varied noise and quiet for fNIRS data collection. Linear fitting was employed in MATLAB to eliminate slow drifts during preprocessing and event-related design analysis. The false discovery rate (FDR) procedure was applied in IBM SPSS Statistics 26.0 to control the false positive rate in multiple comparison analyses.
RESULTS: When the ill group and the healthy control group were stimulated by pink noise, there was a significant difference in blood oxygen concentration (P < 0.05), and the healthy control group exhibited a high activation, according to the fNIRS measurement data. The blood oxygen concentration level in the patient group was dramatically enhanced after one month of acupuncture therapy under the identical stimulation task settings, and it was favorably connected with the levels of THI and TEQ scales.
CONCLUSIONS: Using sensorineural tinnitus illness as an example, fNIRS technology has the potential to disclose future pathological study on subjective diseases throughout time. Other clinical disorders involving the temporal lobe and adjacent brain areas may also be examined, in addition to tinnitus-related brain alterations.