PDF(Pubmed)
Abstract：
Memory consolidation relies in part on the reactivation of previous experiences during sleep. The precise interplay of sleep-related oscillations (slow oscillations, spindles and ripples) is thought to coordinate the information flow between relevant brain areas, with ripples mediating memory reactivation. However, in humans empirical evidence for a role of ripples in memory reactivation is lacking. Here, we investigated the relevance of sleep oscillations and specifically ripples for memory reactivation during human sleep using targeted memory reactivation. Intracranial electrophysiology in epilepsy patients and scalp EEG in healthy participants revealed that elevated levels of slow oscillation - spindle activity coincided with the read-out of experimentally induced memory reactivation. Importantly, spindle-locked ripples recorded intracranially from the medial temporal lobe were found to be correlated with the identification of memory reactivation during non-rapid eye movement sleep. Our findings establish ripples as key-oscillation for sleep-related memory reactivation in humans and emphasize the importance of the coordinated interplay of the cardinal sleep oscillations.
摘要：
记忆巩固部分依赖于睡眠期间先前体验的重新激活。与睡眠相关的振荡(缓慢振荡，纺锤和波纹)被认为协调相关大脑区域之间的信息流，涟漪介导记忆的重新激活。然而,在人类中，缺乏涟漪在记忆再激活中的作用的经验证据。这里,我们使用有针对性的记忆再激活研究了睡眠振荡和特定波纹与人类睡眠期间记忆再激活的相关性。癫痫患者的颅内电生理学和健康参与者的头皮脑电图显示，缓慢振荡-纺锤体活动的水平升高与实验诱导的记忆再激活的读出相吻合。重要的是,发现从内侧颞叶颅内记录的纺锤锁定波纹与非快速眼动睡眠期间记忆再激活的识别相关。我们的发现将涟漪确立为人类与睡眠相关的记忆重新激活的关键振荡，并强调了基本睡眠振荡协调相互作用的重要性。
