Abstract：
We present a young woman with clozapine-resistant schizoaffective disorder who was treated with maintenance electroconvulsive therapy and multiple antipsychotics but continued to have auditory hallucinations. She had a haemorrhagic stroke secondary to a ruptured arteriovenous malformation at the right superior temporal gyrus, which was excised during emergency craniotomy. Despite having neurological deficits after the stroke, she reported cessation of auditory hallucinations. Magnetic resonance imaging of the brain showed Wallerian degeneration over the right temporal region. Personalised neuromodulation intervention may be a more effective treatment option for clozapine-resistant schizophrenia.
摘要：
我们介绍了一名患有氯氮平耐药性分裂情感障碍的年轻女性，她接受了维持电惊厥治疗和多种抗精神病药的治疗，但仍有幻听。她患有出血性中风，继发于右颞上回动静脉畸形破裂，在紧急开颅手术中切除。尽管中风后有神经功能缺损，她报告说幻听停止了。大脑的磁共振成像显示右侧颞区的Wallerian变性。个性化神经调节干预可能是氯氮平耐药精神分裂症的更有效治疗选择。
