背景:神经肌肉阻断剂的作用可以通过给予新斯的明逆转,当使用四组(TOF)刺激存在两个抽搐时。然而,在老年患者中,关于何时使用新斯的明的可用数据有限.我们假设TOF(TOF-2)后两次抽搐的时间在0.6mg/kg罗库溴铵后比0.9mg/kg罗库溴铵后短。此外,我们假设达到TOF-2的时间在罗库溴铵0.3mg/kg后比在罗库溴铵0.6mg/kg后短.
方法:这是对50例>80岁的老年患者进行的二次分析;16例患者接受了0.6mg/kg的罗库溴铵,另有16名患者接受了0.9毫克/千克的罗库溴铵;最后,18例患者接受了0.3mg/kg的罗库溴铵。患者接受全静脉麻醉,用加速肌电图监测神经肌肉阻滞。
结果:罗库溴铵0.6mg/kg后达到TOF-2的时间短于罗库溴铵0.9mg/kg后:37分钟。对59分钟。(差异:22分钟。(95%置信区间(CI):10至33分钟。),p=0.0007)。罗库溴铵0.3mg/kg后的TOF-2时间短于罗库溴铵0.6mg/kg后的时间:19分钟。与37分钟。(差异:18分钟。(95%CI:11至25分钟。),p=0.00006)。然而,接受0.3mg/kg的患者中只有33%获得了完全的效果,即TOF-0。
结论:达到TOF-2的时间在罗库溴铵0.6mg/kg后比0.9mg/kg后短,在罗库溴铵0.3mg/kg后比0.6mg/kg后短。
背景:这项工作得到了部门来源的支持。
背景:这项研究是对两项临床试验的二次分析。
结果:gov(NCT04512313),(NCT03857750)。
BACKGROUND: The effect of neuromuscular blocking agents may be reversed by administration of neostigmine, when two twitches are present using train-of-four (TOF) stimulation. However, in elderly patients, limited data are available about when to administer neostigmine. We hypothesised that time to two twitches after TOF (TOF-2) was shorter after rocuronium 0.6 mg/kg than after rocuronium 0.9 mg/kg. Also, we hypothesised that time to TOF-2 would be shorter after rocuronium 0.3 mg/kg than after rocuronium 0.6 mg/kg.
METHODS: This was a secondary analysis of 50 elderly patients > 80 years; 16 patients received rocuronium 0.6 mg/kg, another 16 patients received rocuronium 0.9 mg/kg; and, finally, 18 patients received rocuronium 0.3 mg/kg. Patients received total intravenous anaesthesia, and neuromuscular block was monitored with acceleromyography.
RESULTS: Time to TOF-2 was shorter after rocuronium 0.6 mg/kg than after rocuronium 0.9 mg/kg: 37 min. versus 59 min. (difference: 22 min. (95% confidence intervals (CI): 10 to 33 min.), p = 0.0007). Time to TOF-2 after rocuronium 0.3 mg/kg was shorter than after rocuronium 0.6 mg/kg: 19 min. versus 37 min. (difference: 18 min. (95% CI: 11 to 25 min.), p = 0.00006). However, only 33% of the patients receiving 0.3 mg/kg obtained full effect i.e. TOF-0.
CONCLUSIONS: Time to TOF-2 was shorter after rocuronium 0.6 mg/kg than after 0.9 mg/kg and shorter after rocuronium 0.3 mg/kg than after 0.6 mg/kg.
BACKGROUND: This work was supported by departmental sources.
BACKGROUND: This study was a secondary analysis of two clinical trials.
RESULTS: gov (NCT04512313), (NCT03857750).