PDF(Pubmed)
Abstract：
Background: There have been few studies comparing the effects of high- and low-dose rocuronium during cesarean section by directly measuring the concentration. Therefore, we conducted a study to examine the blood concentrations and clinical effects of both doses of rocuronium on mothers and fetuses. Methods: Eighteen patients were randomly assigned to two groups: C Group (0.6 mg/kg), and H Group, (1.0 mg/kg). The primary outcome was the comparison of umbilical vein rocuronium concentration between two groups. We assessed ease of intubation, time from rocuronium administration to some TOF points, post-anesthesia care unit (PACU) stay time, infused remifentanil dose, maternal rocuronium concentration, and Apgar scores. Results: No differences were observed in demographic data, ease of intubation, PACU stay time, 1 min Apgar scores, umbilical venous blood gas analysis between both groups. However, the time from rocuronium administration to T3 disappearance was shorter (p=0.009) and time to T1 and T2 reappearance were longer (p=0.003, p=0.009) in H group than that in C group. The administered remifentanil dose (p=0.042) was lower in the H group than in the C group. Rocuronium concentrations in the umbilical vein (p=0.004) and maternal vein before cord clamping (p=0.002) and at discharge (p<0.001) were also found to be higher in the H group than in the C group. Conclusions: We observed no prolongation of PACU stay, and no differences in Apgar scores in H group compared to C group. It suggests that 1.0 mg/kg of rocuronium has no negative effects on the fetus and mother in cesarean section.
摘要：
背景：很少有研究通过直接测量浓度来比较高剂量和低剂量罗库溴铵在剖宫产中的作用。因此,我们进行了一项研究，以检查两种剂量的罗库溴铵对母亲和胎儿的血液浓度和临床影响。方法:18例患者随机分为两组:C组(0.6mg/kg),H集团,（1.0mg/kg）。主要结果是比较两组之间的脐静脉罗库溴铵浓度。我们评估了插管的难易程度，从罗库溴铵给药到一些TOF点的时间，麻醉后护理单元（PACU）停留时间，注入瑞芬太尼剂量，母体罗库溴铵浓度，和阿普加得分。结果：在人口统计学数据中没有观察到差异，易于插管，PACU停留时间,1分钟阿普加得分，两组之间的脐静脉血气分析。然而,H组罗库溴铵给药到T3消失的时间短于C组(p=0.009),T1和T2重现时间长于C组(p=0.003,p=0.009).H组的瑞芬太尼给药剂量(p=0.042)低于C组。在脐带夹闭前（p=0.002）和出院时（p<0.001）的脐静脉（p=0.004）和母体静脉中的罗库溴铵浓度在H组中也高于C组。结论：我们观察到PACU停留时间没有延长，H组Apgar评分与C组相比无差异。提示1.0mg/kg罗库溴铵在剖宫产术中对胎儿和母亲无不良影响。
