PDF(Pubmed)
Abstract：
OBJECTIVE: In our study, we aimed to compare the effect of standard rapid sequence intubation protocol and the application of rocuronium priming technique on the procedure time and hemodynamic profile.
METHODS: Patients who applied to the emergency department and needed rapid sequence intubation were included in our study, which we conducted with a randomized controlled design. Randomization in the study was made according to the order of arrival of the cases. Rapid sequence intubation was performed in the standard group. In the priming group, 10% of the rocuronium dose was administered approximately 3 min before the induction agent. Intubation time, amount of drug used, vital signs, and end-tidal CO2 level before and after intubation used to confirm intubation were recorded.
RESULTS: A total of 52 patients were included in the study, of which 26 patients were included in the standard group and 26 patients in the priming group. While intubation time was 121.2±21.9 s in the standard group, it was calculated as 68.4±11.6 s in the priming group (p<0.001). While the mean arterial pressure was 58.3±26.6 mmHg in the standard group after intubation, it was 80.6±21.1 mmHg in the priming group (p=0.002).
CONCLUSIONS: It was observed that priming with rocuronium shortened the intubation time and preserved the hemodynamic profile better.
BACKGROUND: NCT05343702.
METHODS: Patients who applied to the emergency department and needed rapid sequence intubation were included in our study, which we conducted with a randomized controlled design. Randomization in the study was made according to the order of arrival of the cases. Rapid sequence intubation was performed in the standard group. In the priming group, 10% of the rocuronium dose was administered approximately 3 min before the induction agent. Intubation time, amount of drug used, vital signs, and end-tidal CO2 level before and after intubation used to confirm intubation were recorded.
RESULTS: A total of 52 patients were included in the study, of which 26 patients were included in the standard group and 26 patients in the priming group. While intubation time was 121.2±21.9 s in the standard group, it was calculated as 68.4±11.6 s in the priming group (p<0.001). While the mean arterial pressure was 58.3±26.6 mmHg in the standard group after intubation, it was 80.6±21.1 mmHg in the priming group (p=0.002).
CONCLUSIONS: It was observed that priming with rocuronium shortened the intubation time and preserved the hemodynamic profile better.
BACKGROUND: NCT05343702.
摘要：
目的：在我们的研究中，我们的目的是比较标准的快速顺序插管方案和应用罗库溴铵引发技术对手术时间和血流动力学的影响。
方法：应用于急诊科并需要快速顺序插管的患者被纳入我们的研究，我们进行了随机对照设计。研究中的随机化是根据病例的到达顺序进行的。标准组进行快速顺序插管。在启动组中，在诱导剂之前约3分钟施用10%的罗库溴铵剂量。插管时间,使用的药物数量，生命体征,记录用于确认插管的插管前后的呼气末CO2水平。
结果：本研究共纳入52例患者，其中26例患者被纳入标准组，26例患者被纳入启动组。标准组插管时间为121.2±21.9s,启动组计算为68.4±11.6s(p<0.001)。标准组插管后平均动脉压为58.3±26.6mmHg,启动组为80.6±21.1mmHg(p=0.002)。
结论：观察到罗库溴铵的灌注缩短了插管时间，并更好地保持了血流动力学曲线。
背景：NCT05343702。
方法：应用于急诊科并需要快速顺序插管的患者被纳入我们的研究，我们进行了随机对照设计。研究中的随机化是根据病例的到达顺序进行的。标准组进行快速顺序插管。在启动组中，在诱导剂之前约3分钟施用10%的罗库溴铵剂量。插管时间,使用的药物数量，生命体征,记录用于确认插管的插管前后的呼气末CO2水平。
结果：本研究共纳入52例患者，其中26例患者被纳入标准组，26例患者被纳入启动组。标准组插管时间为121.2±21.9s,启动组计算为68.4±11.6s(p<0.001)。标准组插管后平均动脉压为58.3±26.6mmHg,启动组为80.6±21.1mmHg(p=0.002)。
结论：观察到罗库溴铵的灌注缩短了插管时间，并更好地保持了血流动力学曲线。
背景：NCT05343702。
