微/纳米马达(MNM)是微型设备,可以通过化学反应或物理过程产生能量,利用这种能量进行运动。由于它们的体积小,自我推进,在小范围内精确定位,以及访问微环境的能力,MNM已应用于各个领域,包括传感,生物医学应用,和污染物吸附。然而,食品级MNM的发展及其在食品输送系统中的应用几乎没有报道。目前,分解有各种问题,氧化,或无法维持某些营养素或生物活性物质的活性,例如姜黄素(Cur)在食品中的有限应用。与传统的递送系统相比,MNM可以根据需要调整运输速度和方向,在输送过程中有效保护生物活性物质,实现高效运输。因此,本研究以多糖为底物,使用一个简单的,快速,和无污染模板法制备多糖基微管(PMTs)和多糖基微/纳米马达(PMNMs)。PMNM可以通过对四氧化三铁(Fe3O4)进行改性来实现多功能推进,铂(Pt),和葡萄糖氧化酶(GOx)。Fe-PMNMs和Pt-PMNMs表现出优异的光热转换性能,显示在光热疗法的应用前景。此外,PMNMs可以有效地提供姜黄素,实现营养物质的有效输送和发挥系统的抗炎性能。
Micro/nanomotors (MNMs) are miniature devices that can generate energy through chemical reactions or physical processes, utilizing this energy for movement. By virtue of their small size, self-propulsion, precise positioning within a small range, and ability to access microenvironments, MNMs have been applied in various fields including sensing, biomedical applications, and pollutant adsorption. However, the development of food-grade MNMs and their application in food delivery systems have been scarcely reported. Currently, there are various issues with the decomposition, oxidation, or inability to maintain the activity of some nutrients or bioactive substances, such as the limited application of curcumin (Cur) in food. Compared to traditional delivery systems, MNMs can adjust the transport speed and direction as needed, effectively protecting bioactive substances during delivery and achieving efficient transportation. Therefore, this study utilizes polysaccharides as the substrate, employing a simple, rapid, and pollution-free template method to prepare polysaccharide-based microtubes (PMTs) and polysaccharide-based micro/nanomotors (PMNMs). PMNMs can achieve multifunctional propulsion by modifying ferrosoferric oxide (Fe3O4), platinum (Pt), and glucose oxidase (GOx). Fe-PMNMs and Pt-PMNMs exhibit excellent photothermal conversion performance, showing promise for applications in photothermal therapy. Moreover, PMNMs can effectively deliver curcumin, achieving the effective delivery of nutrients and exerting the anti-inflammatory performance of the system.