Abstract：
In 2021, we published three papers related to the anti-inflammatory effects of food ingredients. The present paper reports the effects of vitamin E homologs and sweet basil powder. In these papers, we investigated whether inflammation occurs in the adipose tissue of mice fed a high-fat and high-sucrose diet for 16 weeks. Inflammatory cytokine gene expression was significantly higher in the epididymal fat of the high-fat and high-sucrose diet group than in that of the control diet group. However, the addition of α-tocopherol or δ-tocopherol to the diet could not restrain the inflammation of mice epididymal fats. Thereafter, we investigated the anti-inflammatory effects of α- and δ-tocopherols using the co-cultured cells. Consequently, we clarified that δ-tocopherol inhibited the increase in the gene expressions of inflammatory cytokines. We also examined the effect of sweet basil powder on a similar obese mice model. The final body weight in the high-fat and high-sucrose group that received sweet basil powder was significantly lower than that in the high-fat and high-sucrose diet group. Liver weights were also significantly lower in the high-fat and high-sucrose diet group that received sweet basil powder than in the high-fat and high-sucrose diet group, although adipose tissue weights were unchanged in both groups. Furthermore, sweet basil powder tended to inhibit in lipid synthesis in the mice livers. Therefore, we suggested that sweet basil powder inhibited fatty acid synthesis in mice livers, thereby suppressing liver enlargement, and resulting in body weight loss. Moreover, the gene expression of MCP-1 in the adipose tissue of mice fed a high-fat and high-sucrose diet added with sweet basil powder was significantly lower than that of mice fed a high-fat and high-sucrose diet for 12 weeks. Therefore, sweet basil powder inhibited inflammation onset in the adipose tissue of mice. Taken together, the results suggested that food ingredients, especially vitamin E homologs and sweet basil powder, have anti-inflammatory effects on mice adipose tissue and mice adipocyte-induced inflammation.
摘要：
2021年，我们发表了三篇有关食品成分抗炎作用的论文。本文报道了维生素E同系物和甜罗勒粉的作用。在这些文件中,我们调查了高脂高糖饮食16周小鼠的脂肪组织是否发生炎症.高脂高糖饮食组附睾脂肪炎性细胞因子基因表达明显高于对照饮食组。然而,饮食中添加α-生育酚或δ-生育酚不能抑制小鼠附睾脂肪的炎症。此后,我们使用共培养的细胞研究了α-和δ-生育酚的抗炎作用。因此,我们阐明了δ-生育酚抑制炎性细胞因子基因表达的增加。我们还检查了甜罗勒粉对类似肥胖小鼠模型的影响。接受甜罗勒粉的高脂高蔗糖组的最终体重明显低于高脂高蔗糖饮食组。接受甜罗勒粉的高脂肪和高蔗糖饮食组的肝脏重量也明显低于高脂肪和高蔗糖饮食组,尽管两组的脂肪组织重量没有变化。此外，甜罗勒粉倾向于抑制小鼠肝脏的脂质合成。因此,我们认为甜罗勒粉抑制小鼠肝脏脂肪酸合成，从而抑制肝脏肿大，导致体重下降。此外，添加甜罗勒粉的高脂高糖饮食的小鼠脂肪组织中MCP-1的基因表达明显低于高脂高糖饮食12周的小鼠。因此,甜罗勒粉抑制小鼠脂肪组织的炎症发作。一起来看,结果表明，食物成分，尤其是维生素E同源物和甜罗勒粉，对小鼠脂肪组织和小鼠脂肪细胞诱导的炎症有抗炎作用。
