The creation of the universe out of nothing (ex nihilo) is attributable to the eternal God. Would a direct divine intervention be needed for other singular events, such as the origin of life? Taking apart the human being, created to image and resemblance of God, we argue that current scientific knowledge allows us to rationally admit a continuity between the origins of the universe and the emergence of life on Earth. Although the irruption of living beings from inert matter is a leap or discontinuity in creation, a direct intervention of God would not be indispensable. The initial impulse of creation, with matter and energy in a space-time imbalance, could have triggered reactions between the different elements and a self-organization of metabolites, in accordance with natural physical-chemistry laws. This paradoxical increase of complexity ended with a transition from chemistry to biology. It happened when independence, metabolism, heritability, and life cycle took place in a protocellular unit. In this way, the emergence of life on earth could be part of an evolutionary dynamic of the timeless God\'s creative act.

Conceptualising precarity has come to rest on the multi-dimensional and differentiated insecurities of job and worker, this however belies the relationship between structure and experience where precarity originates. To bridge that relationship, I employ the landscape concept to position workers relative to the structural contingency of precarious work. To study this landscape, I conducted an ethnography involving job searching, working, and interviewing workers. While certainly insecure, these jobs displayed parallel characteristics of streamlined hiring and short-notice starts which workers took advantage of. I explore three ideal-typical \'jobs\'-the first, only, and best job-to examine how vulnerability is balanced with contingency to produce precarity. This analysis and the landscape approach locate the political-economic transformation of work in the context of workers\' lives and their labour market position. Taking precarious work is an act of balancing one\'s vulnerabilities in a way that constructs and thus naturalises precarity. Overall, the article contributes an image of an economy where workers have to be opportunistic in a continual struggle for work while stratified by their personal circumstances and position in this labour market.

The concepts of pediatric surge in the United States continue to evolve from a theoretic framework to practical implementation. As disasters become more frequent, ranging from natural to human-caused, children remain a vulnerable population. The coronavirus disease 2019 pandemic and the 2022 to 2023 tripledemic respiratory surge revealed advances and continued challenges in our ability to care for a large influx of pediatric patients. Understanding pediatric surge through the framework of the 4 S\'s (space, staff, stuff, and systems/structures) can identify gaps at multiple levels.

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The question of how local adaptation takes place remains a fundamental question in evolutionary biology. The variation of allele frequencies in genes under selection over environmental gradients remains mainly theoretical and its empirical assessment would help understanding how adaptation happens over environmental clines. To bring new insights to this issue we set up a broad framework which aimed to compare the adaptive trajectories over environmental clines in two domesticated mammal species co-distributed in diversified landscapes. We sequenced the genomes of 160 sheep and 161 goats extensively managed along environmental gradients, including temperature, rainfall, seasonality and altitude, to identify genes and biological processes shaping local adaptation. Allele frequencies at putatively adaptive loci were rarely found to vary gradually along environmental gradients, but rather displayed a discontinuous shift at the extremities of environmental clines. Of the 430 candidate adaptive genes identified, only 6 were orthologous between sheep and goats and those responded differently to environmental pressures, suggesting different putative mechanisms involved in local adaptation in these two closely related species. Interestingly, the genomes of the 2 species were impacted differently by the environment, genes related to signatures of selection were most related to altitude, slope and rainfall seasonality for sheep, and summer temperature and spring rainfall for goats. The diversity of candidate adaptive pathways may result from a high number of biological functions involved in the adaptations to multiple eco-climatic gradients, and a differential role of climatic drivers on the two species, despite their co-distribution along the same environmental gradients. This study describes empirical examples of clinal variation in putatively adaptive alleles with different patterns in allele frequency distributions over continuous environmental gradients, thus showing the diversity of genetic responses in adaptive landscapes and opening new horizons for understanding genomics of adaptation in mammalian species and beyond.

Does genetic background contribute to populations following the same or divergent adaptive trajectories? A recent study by Filipow et al. evolved multiple genetically distinct Pseudomonas aeruginosa strains to an artificial cystic fibrosis lung sputum media. The strains adapted at different rates but converged on similar phenotypes despite their initial diversity.

Infants learn language through the back-and-forth interactions with their parents where they \"serve\" by uttering sounds, gesturing, or looking and parents \"return\" in prompt (i.e., close in time) and meaningful (i.e., semantically relevant to the object of interest) ways. In a sample of 9-month-old infants (n = 148) and their mothers and fathers (n = 296 parents) from ethnically and socioeconomically diverse backgrounds, we examined the associations between \"serve and return\" (SR) parent-child interactions and children\'s language skills at 18 and 24 months. We also examined the moderation effects between maternal and paternal SR interactions on language outcomes. SR interactions were transcribed and coded from videotaped parent-child toy play activities during home visits. We report three findings. First, mothers who provided more meaningful responses to their child\'s serves at 9 months had children with higher expressive language scores at 18 months. Second, fathers\' prompt responses (i.e., within 3 s) at 9 months were associated with higher receptive language scores at 18 months, but their meaningful responses were negatively associated with receptive language scores at 24 months. Third, the negative association between fathers\' meaningful responses and children\'s receptive language scores was reduced (compensated) when mothers\' meaningful responses were high. Findings show that infants in ethnically and socioeconomically diverse families engage in frequent SR interactions with both mothers and fathers, who make unique contributions to infants\' language development. We discuss implications for programs and policies that aim to promote early language development and reduce gaps in school readiness.

Although their perspectives and approaches vary, existing criminological theories are all based on the deterministic optimism that the crucial causes of criminal behavior must exist and can be uncovered. However, no key factor can fully explain the causes of criminal behavior. All factors that directly affect the occurrence of criminal behavior are important, and contingency is always at work. More feasible crime prevention and control measures can be proposed only considering the contingency factor. The aim of this study is to point out the limitations of the deterministic view of existing criminological theories that explain the causes of crime after knowing the results, and simultaneously to propose the contingency model with viable alternative solutions.

A single non-contingent dose of cocaine reinstates extinguished lever pressing behavior in rats trained to self-administer cocaine. This represents a model of relapse in cocaine use disorder and the number of lever presses has been the standard measure. Lever pressing behavior during self-administration occurs only when cocaine levels are below the satiety threshold and above the remission/priming threshold, a range termed the compulsion zone. Calculated cocaine levels at the time of each lever press during an FR1 self-administration session and following a single non-contingent dose of cocaine were compared. The mean latency to lever pressing behavior was dose dependent and ranged from 1 to 11 min after cocaine doses of 2 or 12 μmol/kg, respectively. This is consistent with higher cocaine doses producing levels above satiety threshold that take more time to fall back to that threshold. The level of cocaine when lever pressing occurred was similar whether cocaine was self-administered or after a single dose of cocaine. The number of lever presses after a single cocaine dose was variable and poorly dose dependent. The latency to the start of lever pressing behavior is a more reliable dependent measure than the number of lever presses. In addition, lever pressing behavior occurs only when cocaine levels are within the compulsion zone. The compulsion zone theory not only explains maintained cocaine self-administration behavior, but also explains the reinstatement of lever pressing behavior in response to a single non-contingent cocaine dose.

One of the most important challenges for a developing infant is learning how best to allocate their attention and forage for information in the midst of a great deal of novel stimulation. We propose that infants of altricial species solve this challenge by learning selectively from events that are contingent on their immature behavior, such as babbling. Such a contingency filter would focus attention and learning on the behavior of social partners, because social behavior reliably fits infants\' sensitivity to contingency. In this way a contingent response by a caregiver to an immature behavior becomes a source of learnable information - feedback - to the infant. Social interactions with responsive caregivers afford infants opportunities to explore the impacts of their immature behavior on their environment, which facilitates the development of socially guided learning. Furthermore, contingent interactions are opportunities to make and test predictions about the efficacy of their social behaviors and those of others. In this chapter, we will use prelinguistic vocal learning to exemplify how infants use their developing vocal abilities to elicit learnable information about language from their social partners. Specifically, we review how caregivers\' contingent responses to babbling create information that facilitates infant vocal learning and drives the development of communication. Infants play an active role in this process, as their developing predictions about the consequences of their actions serve to further refine their allocation of attention and drive increases in the maturity of their vocal behavior.