这项研究旨在研究血清胆固醇水平与血清中锌(Zn)和铜(Cu)的比例与心血管疾病(CVD)发病率之间的关系。在研究的第一阶段,招募了9704名年龄在35至65岁之间的个体。队列研究的第二阶段包括7561名完成10年随访的参与者。在研究的基线测量的变量包括性别,年龄,收缩压(SBP),舒张压(DBP);生化参数,包括血清铜,Zn,铜锌比(Cu/Zn),锌铜比(Zn/Cu);由甘油三酯(TG)组成的空腹脂质分布,总胆固醇(TC),高密度脂蛋白(HDL),低密度脂蛋白(LDL)以及空腹血糖,和甘油三酯-葡萄糖(TyG)指数。应用决策树(DT)和逻辑回归(LR)模型来检查上述因素与CVD之间的关系。在7561名参与者中,有837名个体(378名男性和459名女性)被诊断出CVD。根据LR模型,SBP,TC,HDL,年龄,Zn/Cu,男性和SBP的TyG指数,年龄,TyG指数,HDL,TC,Cu/Zn,女性的Cu与CVD的相关性最高(p值≤0.033)。基于DT算法,88%的男性SPB<129.66mmHg,年龄较小(年龄<53岁),TyG指数<9.53,173≤TC<187mg/dL,HDL≥32mg/dL的CVD风险最低。此外,98%的女性SBP<128mmHg,TyG指数<9.68,年龄<44,TC<222mg/dL,HDL≥63.7mg/dL的CVD风险最低。可以得出结论,男性的Zn/Cu和女性的Cu/Zn,伴随着血脂异常和SBP,可以显著预测伊朗东北部人群的心血管疾病风险。
This study aimed to examine the relationship between serum cholesterol levels and the ratio of zinc (Zn) and
copper (Cu) in the blood serum and the incidence of cardiovascular disease (CVD). In Phase I of the study, 9704 individuals between the age of 35 and 65 years were recruited. Phase II of the cohort study comprised 7561 participants who completed the 10-year follow-up. The variables which were measured at the baseline of the study included gender, age, systolic blood pressure (SBP), diastolic blood pressure (DBP); biochemical parameters including serum Cu, Zn,
copper-zinc ratio (Cu/Zn), zinc-
copper ratio (Zn/Cu); fasted lipid profile consisting of triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) as well as fasting serum glucose, and triglycerides-glucose (TyG) index. Decision tree (DT) and logical regression (LR) models were applied to examine the relationship between the aforementioned factors and CVD. CVD was diagnosed in 837 individuals (378 males and 459 females) out of 7561 participants. According to the LR models, SBP, TC, HDL, age, Zn/Cu, and TyG index for males and SBP, age, TyG index, HDL, TC, Cu/Zn, and Cu for females had the highest correlation with CVD (p-value ≤ 0.033). Based on the DT algorithm, 88% of males with SPB < 129.66 mmHg, younger age (age < 53 years), TyG index < 9.53, 173 ≤ TC < 187 mg/dL, and HDL ≥ 32 mg/dL had the lowest risk of CVD. Also, 98% of females with SBP < 128 mmHg, TyG index < 9.68, age < 44, TC < 222 mg/dL, and HDL ≥ 63.7 mg/dL had the lowest risk of CVD. It can be concluded that the Zn/Cu for men and Cu/Zn for women, along with dyslipidemia and SBP, could significantly predict the risk of CVD in this cohort from northeastern Iran.