Abstract：
Copper is a vital trace metal element necessary for the functioning of living organisms. It serves as a co-factor or structural component in numerous enzymes, participating in crucial biological metabolic processes. Disruptions in copper homeostasis, whether inherited or acquired, such as copper overload, deficiency, or uneven distribution, can contribute to or exacerbate various diseases, including Menkes disease, Wilson\'s disease, neurodegenerative disorders, anemia, cardiovascular diseases, kidney diseases and cancer. Recent research has highlighted the close correlation between chronic kidney disease and intracellular copper overload. Therefore, renal cells must establish a well-organized and efficient copper regulation network to maintain intracellular copper homeostasis. This review summarizes the processes of copper uptake, intracellular trafficking, storage, and excretion in renal cells, and elucidates the underlying mechanisms involved, aiming to provide a theoretical foundation and potential therapeutic targets for the fundamental investigation and clinical management of kidney-related diseases.
摘要：
铜是生物体功能所必需的重要痕量金属元素。它在许多酶中充当辅因子或结构成分，参与关键的生物代谢过程。铜稳态的破坏，无论是继承的还是后天的，比如铜过载，缺乏,或者分布不均，会导致或加剧各种疾病，包括Menkes病,威尔逊病,神经退行性疾病，贫血,心血管疾病,肾脏疾病和癌症。最近的研究强调了慢性肾脏病与细胞内铜过载之间的密切关系。因此,肾细胞必须建立一个组织良好和有效的铜调节网络，以维持细胞内铜稳态。这篇综述总结了铜的吸收过程，细胞内贩运，storage,在肾细胞中排泄，并阐明了其中的潜在机制，旨在为肾脏相关疾病的基础研究和临床管理提供理论基础和潜在的治疗目标。
