高热惊厥(FS)在儿科患者中很常见,通常由高于100.4°F(38°C)的高烧引发,通常与病毒或细菌感染有关,如呼吸道或胃肠道感染。最近的研究表明,血清微量元素浓度可能在FS的发生中起作用。本研究旨在评估儿科患者血清微量元素水平与FS之间的关系。全面搜索四个数据库,包括Scopus,WebofScience,PubMed,和谷歌学者,进行到2024年2月。这项研究遵循了PICO的结构,关注人群(FS儿科患者),干预(血清硒浓度,锌,镁,和铜),比较(有或没有控制),和结果(FS的发生)。使用纽卡斯尔-渥太华量表(NOS)工具评估纳入的观察性研究的方法学质量。在总共168篇论文中,37符合本荟萃分析的纳入标准,涵盖2018年至2023年发表的研究。与对照组相比,FS儿科患者的血清锌水平较低(SMD:-1.25,95%CI:-1.47,-1.03)。相反,与FS组相比,对照组的血清铜水平更高(SMD:0.43,95%CI:0.04,0.82).此外,与对照组相比,FS组中检测到较低的血清镁水平(SMD:-0.76,95%CI:-1.57,0.05),而FS组的血清硒水平比对照组低大约两倍(SMD:-2.23,95%CI:-2.76,-1.70)。我们的荟萃分析表明,与对照组相比,FS患儿的血清微量元素浓度较低。有必要进一步研究以阐明微量元素在FS发病机理中的潜在作用。这项荟萃分析和系统评价已在国际前瞻性系统评价登记册中注册(PROSPEROID:CRD42024519163)。注册表URL:https://www。crd.约克。AC.uk/prospro/display_record.php?ID=CRD42024519163注册表号:CRD42024519163。
Febrile seizures (FS) are a common occurrence in pediatric patients and are typically triggered by high fevers above 100.4°F (38°C), often associated with viral or bacterial infections such as respiratory or gastrointestinal infections. Recent research suggests that the serum concentration of trace elements may play a role in the occurrence of FS. This study aimed to assess the association between serum levels of trace elements and FS in pediatric patients. A comprehensive search of four databases, including Scopus, Web of Science, PubMed, and Google Scholar, was conducted up to February 2024. The study followed the PICO structure, focusing on the Population (pediatric patients with FS), Intervention (serum concentrations of selenium, zinc, magnesium, and
copper), Comparison (with or without controls), and Outcome (occurrence of FS). The methodological quality of the included observational studies was assessed using the Newcastle-Ottawa Scale (NOS) tool. Out of a total of 168 papers, 37 met the inclusion criteria for this meta-analysis, covering studies published between 2018 and 2023. Lower serum zinc levels were observed in pediatric patients with FS compared to control groups (SMD: -1.25, 95% CI: -1.47, -1.03). Conversely, higher serum
copper levels were found in control groups compared to those with FS (SMD: 0.43, 95% CI: 0.04, 0.82). Additionally, lower serum magnesium levels were detected in the FS group compared to controls (SMD: -0.76, 95% CI: -1.57, 0.05), while serum selenium levels were approximately two times lower in the FS group than in controls (SMD: -2.23, 95% CI: -2.76, -1.70). Our meta-analysis suggests that pediatric patients with FS have lower serum concentrations of trace elements compared to controls. Further research is warranted to elucidate the potential role of trace elements in the pathogenesis of FS. This meta-analysis and systematic
review was registered in the International prospective register of systematic reviews (PROSPERO ID: CRD42024519163). Registry URL: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024519163 registry number: CRD42024519163.