■切口形式的医学表现,烧伤,创伤会触发自然的伤口愈合过程,涉及细胞之间复杂的相互作用。巴西林和其他次级代谢产物在Sappan木材中发现具有许多生物活性的品质,包括消炎药,抗癌,和抗氧化性能。
■本研究旨在研究苏木(CaesalpiniaSappanL.)乙醇提取物局部对白化病大鼠切口伤口愈合的功效。
■20只雄性大鼠随机分为5组,重复4次,即,(C-)是以软膏为基础的治疗,(C+)用10%聚维酮碘处理,(T1,T2和T3组)用苏木提取物浓度为6.5%处理,15%,30%,分别。每天两次对受伤区域局部施用治疗,持续15天。根据以下参数对伤口愈合进行组织学评估胶原沉积,多形核中性粒细胞(PMN),血管生成,和纤维化程度使用H&E染色。使用酶联免疫吸附测定(ELISA)方法评估IL-2水平。在第8天和第15天计算伤口长度减少。
■因此,6.5%(T1),15%(T2),与基于软膏(C-)和聚维酮碘(C)组相比,30%(T3)苏木提取物组的胶原蛋白沉积显着改善(p<0.05),PMN,血管生成,纤维化程度,和IL-2水平。特别是,与其他组相比,6.5%(T1)苏木提取物组显着突出(p<0.05),在第8天和第15天,伤口愈合参数的提高和伤口长度的减少证明了这一点。
■总而言之,6.5%的苏木提取物显示其适用于改善白化病大鼠的切口伤口愈合。
UNASSIGNED: Medical manifestations in the form of incisions, burns, and trauma will trigger a natural wound-healing process that involves complex interactions between cells. Brazilin and other secondary metabolites found in Sappan wood have numerous bioactive qualities, including anti-inflammatory, anti-cancer, and antioxidant properties.
UNASSIGNED: This study aimed to investigate the efficacy of Sappan wood (
Caesalpinia Sappan L.) ethanol extract topically on the incision wound healing of albino rats.
UNASSIGNED: Twenty male rats were randomly assigned into five groups with four replications, i.e., (C-) was treated ointment-based, (C+) was treated with 10% povidone-iodine, (T1, T2, and T3 groups) were treated with Sappan wood extract concentration for 6.5%, 15%, and 30%, respectively. The treatment was topically administered to wounded areas twice a day for 15 days. Wound healing was evaluated histologically as the following parameters collagen deposition, polymorphonuclear neutrophils (PMN), angiogenesis, and fibrosis degree using H&E staining. IL-2 level was evaluated using the enzyme-linked immunosorbent assay (ELISA) method. Wound length reduction was calculated on days 8 and 15.
UNASSIGNED: As a result, the 6.5% (T1), 15% (T2), and 30% (T3) Sappan wood extract groups were improved significantly (p < 0.05) compared to ointment-based (C-) and povidone-iodine (C+) groups on the collagen deposition, PMN, angiogenesis, fibrosis degree, and IL-2 level. In particular, the 6.5% (T1) Sappan wood extract group was highlighted significantly (p < 0.05) compared to other groups, evidenced by the improvisation of wound healing parameters and reduction of wound length on days 8 and 15.
UNASSIGNED: In conclusion, a 6.5% Sappan wood extract revealed its applicability to improve incision wound healing in albino rats.