Abstract：
Eight previously undescribed diterpenoids, caesamins A-H (1-8), were separated and identified from the seeds of Caesalpinia minax Hance. Their structures were characterized by extensive spectroscopic data and X-ray crystallographic analysis. Structurally, caesamin A (1) is the first cassane-type diterpenoid with a C23 carbon skeleton containing an unusual isopropyl. Caesamin F (6) represents the first example of cleistanthane diterpenoid from the genus Caesalpinia. Caesamins B (2) and F (6) exhibited inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 45.67 ± 0.92 and 42.99 ± 0.24 μM, comparable to positive control 43.69 ± 2.62 μM of NG-Monomethyl-L-arginine. Furthermore, the chemotaxonomic significance of the isolates was discussed.
摘要：
八种以前没有描述的二萜，维生素A-H（1-8），从CaesalpiniaminaxHance的种子中分离并鉴定。它们的结构通过广泛的光谱数据和X射线晶体学分析进行了表征。在结构上,caesaminA（1）是第一种具有C23碳骨架的卡萨烷型二萜，其中含有不寻常的异丙基。CaesaminF（6）代表来自Caesalpinia属的cleistanthane二萜的第一个例子。维生素B（2）和F（6）在RAW264.7巨噬细胞中表现出对LPS诱导的一氧化氮产生的抑制活性，IC50值为45.67±0.92和42.99±0.24μM，与阳性对照43.69±2.62μM的NG-甲基-L-精氨酸相当。此外，讨论了分离株的化学分类学意义。
