{Reference Type}: Journal Article
{Title}: Structurally diverse diterpenoids from the seeds of Caesalpinia minax Hance and their bioactivities.
{Author}: Tu WC;Ding LF;Song LD;Li YJ;Yan RC;Wu Y;Feng WY;Wu XD;
{Journal}: Phytochemistry
{Volume}: 225
{Issue}: 0
{Year}: 2024 Sep 20
{Factor}: 4.004
{DOI}: 10.1016/j.phytochem.2024.114189
{Abstract}: Eight previously undescribed diterpenoids, caesamins A-H (1-8), were separated and identified from the seeds of Caesalpinia minax Hance. Their structures were characterized by extensive spectroscopic data and X-ray crystallographic analysis. Structurally, caesamin A (1) is the first cassane-type diterpenoid with a C23 carbon skeleton containing an unusual isopropyl. Caesamin F (6) represents the first example of cleistanthane diterpenoid from the genus Caesalpinia. Caesamins B (2) and F (6) exhibited inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 45.67 ± 0.92 and 42.99 ± 0.24 μM, comparable to positive control 43.69 ± 2.62 μM of NG-Monomethyl-L-arginine. Furthermore, the chemotaxonomic significance of the isolates was discussed.