■疾病X表示未识别的感染可能在全球范围内传播并开始大流行的可能性。这项研究探索了新兴的非脊髓灰质炎肠道病毒(NPEV)的各个方面,作为“X病”的可能来源,“世界卫生组织宣布的神秘特工,并讨论了NPEV对全球公共卫生的潜在影响。
■在这篇透视文章中,我们从谷歌学者等公开来源收集信息,PubMed,还有Scopus.我们使用了NPEV,病毒性疾病,大流行,和人畜共患疾病作为关键词。我们从最相关的文章中提取信息。
■由NPEV引起的值得注意的爆发包括肠道病毒D68(EV-D68)和肠道病毒A71(EV-A71),在许多其他人中。专注于治疗和预防成分,替代治疗模式,以及广谱抗病毒药物的发展,这个分析着眼于起源,流行病学,遗传改变,传输动力学,和NPEV的疾病病理生理学。审查中提供的信息表明了当前对NPEV的风险评估,考虑到以下因素:研究和治疗干预的必要性,临床表现的多样性,遗传变异对毒力的影响,尽管疫苗接种努力,但持续出现,反复爆发,以及这些病毒的全球影响。
■根据人畜共患的起源,NPEV有可能引发全球大流行,并敦促完全做好准备,持续研究,合作,以及在不断变化的全球环境中防治新出现的传染病的综合战略。现在是时候认识到遵守安全和健康法律以预防这些疾病的重要性了。
UNASSIGNED: Disease X represents the possibility that an unidentified infection may spread globally and start a pandemic. This study explored various aspects of emerging non-polio enteroviruses (NPEVs) as a possible source of \"Disease X,\" an enigmatic agent declared by the World Health Organization, and discussed the potential impact of NPEVs on global public health.
UNASSIGNED: In this perspective article, we collected information from publicly available sources such as Google Scholar, PubMed, and Scopus. We used NPEVs, viral diseases, pandemics, and zoonotic diseases as keywords. We extracted information from the most relevant articles.
UNASSIGNED: Notable outbreaks caused by NPEVs include enterovirus D68 (EV-D68) and enterovirus A71 (EV-A71), among many others. With a focus on therapeutic and preventative components, alternate modes of therapy, and the development of broad-spectrum antivirals, this analysis looks at the origin, epidemiology, genetic alterations, transmission dynamics, and disease pathophysiology of NPEVs. The information presented in the review indicates the current risk assessment of NPEVs, taking into account the following factors: the need for research and therapeutic interventions, the diversity of clinical manifestations, the impact of genetic variability on virulence, the persistence of emergence despite vaccination efforts, recurrent outbreaks, and the global impact of these viruses.
UNASSIGNED: There is a possibility that NPEVs could trigger global pandemics based on their zoonotic origins and urges for complete readiness, continuous research, cooperation, and a comprehensive strategy to combat emerging infectious diseases in a constantly changing global environment. It is peak time to acknowledge how important it is to abide by safety and health laws to prevent these illnesses.