PDF(Pubmed)
Abstract：
Ferrets are highly susceptible to a wide range of mycobacteria, mainly M. bovis, M. avium, and M. triplex. Therefore, ferrets pose a risk of transmission of mycobacteriosis, especially zoonotically relevant tuberculosis. The aim of this study was to describe the findings of M. xenopi mycobacteriosis in a pet ferret and emphasize its zoonotic potential. A pet ferret had a history of weight loss, apathy, hyporexia, and hair loss. Abdominal ultrasound revealed splenomegaly with two solid masses and cystic lesions of the liver. Fine-needle aspiration cytology revealed numerous acid-fast bacilli in epithelioid cells, thus leading to the suspicion of mycobacterial infection. Because of its poor general condition, the ferret was euthanized. Necropsy examination revealed generalized granulomatous lymphadenitis, pneumonia, myocarditis, splenitis, and hepatitis. Histologically, in all organs, there were multifocal to coalescing areas of inflammatory infiltration composed of epithelioid macrophages, a low number of lymphocytes, and plasma cells, without necrosis nor multinucleated giant cells. Ziehl-Neelsen staining detected the presence of numerous (multibacillary) acid-fast bacteria, which were PCR-typed as M. xenopi. This is the first study showing the antimicrobial susceptibility testing of M. xenopi in veterinary medicine, describing the resistance to doxycycline. Overall, our results could facilitate further diagnosis and provide guidelines for the treatment protocols for such infections.
摘要：
雪貂对各种分枝杆菌高度敏感,主要是M.Bovis,M.avium,还有M.Triplex.因此,雪貂有传播分枝杆菌病的风险，特别是动物共患病相关的结核病。这项研究的目的是描述宠物雪貂中异种分枝杆菌病的发现，并强调其人畜共患潜力。一只宠物雪貂有减肥史,冷漠,缺氧,和脱发。腹部超声显示脾肿大，有两个实体肿块和肝脏囊性病变。细针穿刺细胞学检查显示上皮样细胞中有许多抗酸杆菌，从而导致对分枝杆菌感染的怀疑。由于它的一般状况较差，雪貂被安乐死了.尸检显示全身性肉芽肿性淋巴结炎，肺炎,心肌炎,脾炎,和肝炎。组织学上,在所有器官中，有由上皮样巨噬细胞组成的炎症浸润的多灶性至聚结区域，淋巴细胞数量少，和浆细胞，没有坏死也没有多核巨细胞.Ziehl-Neelsen染色检测到许多（多杆菌）抗酸细菌的存在，PCR分型为M.xenopi。这是第一项显示兽医学中对M.xenopi进行抗菌敏感性测试的研究，描述对多西环素的耐药性。总的来说,我们的结果有助于进一步诊断,并为此类感染的治疗方案提供指导.
