背景:坏死性小肠结肠炎(NEC)是一种严重的胃肠道急症,影响早产和低出生体重新生儿。血清淀粉样蛋白A(SAA),降钙素原(PCT),和高迁移率族蛋白1(HMGB1)已成为NEC的潜在生物标志物,因为它们在炎症反应中的作用,组织损伤,和免疫调节。
目的:评估SAA的诊断价值,PCT,和HMGB1在新生儿NEC的背景下。
方法:本研究回顾性分析了48例确诊为NEC的新生儿和50例住院健康新生儿的临床资料。临床,放射学,和实验室发现,包括血清SAA,PCT,和HMGB1水平,被收集,并采用了具体的检测方法。通过统计分析评估生物标志物的诊断价值。这是使用卡方检验进行的,t检验,相关分析,和接收机工作特性(ROC)分析。
结果:研究表明血清SAA水平显著升高,PCT,与健康对照相比,诊断为NEC的新生儿的HMGB1水平。相关性分析显示血清SAA之间存在强正相关,PCT,和HMGB1水平和NEC的存在。ROC分析显示对血清SAA的敏感性和特异性,PCT,和HMGB1水平作为潜在的诊断标志物。三种生物标志物的组合模型证明了极高的曲线下面积(0.908)。
结论:血清SAA,PCT,和HMGB1在NEC中的水平被强调。这些生物标志物有可能改善早期检测,风险分层,和关键条件的临床管理。研究结果表明,这些生物标志物可能有助于及时干预并增强受NEC影响的新生儿的预后。
BACKGROUND: Necrotising enterocolitis (NEC) is a critical gastrointestinal emergency affecting premature and low-birth-weight neonates. Serum amyloid A (SAA), procalcitonin (PCT), and high-mobility group box 1 (HMGB1) have emerged as potential biomarkers for NEC due to their roles in inflammatory response, tissue damage, and immune regulation.
OBJECTIVE: To evaluate the diagnostic value of SAA, PCT, and HMGB1 in the context of NEC in newborns.
METHODS: The study retrospectively analysed the clinical data of 48 newborns diagnosed with NEC and 50 healthy newborns admitted to the hospital. Clinical, radiological, and laboratory findings, including serum SAA, PCT, and HMGB1 Levels, were collected, and specific detection methods were used. The diagnostic value of the biomarkers was evaluated through statistical analysis, which was performed using chi-square test, t-test, correlation analysis, and receiver operating characteristic (ROC) analysis.
RESULTS: The study demonstrated significantly elevated levels of serum SAA, PCT, and HMGB1 Levels in newborns diagnosed with NEC compared with healthy controls. The correlation analysis indicated strong positive correlations among serum SAA, PCT, and HMGB1 Levels and the presence of NEC. ROC analysis revealed promising sensitivity and specificity for serum SAA, PCT, and HMGB1 Levels as potential diagnostic markers. The combined model of the three biomarkers demonstrating an extremely high area under the curve (0.908).
CONCLUSIONS: The diagnostic value of serum SAA, PCT, and HMGB1 Levels in NEC was highlighted. These biomarkers potentially improve the early detection, risk stratification, and clinical management of critical conditions. The findings suggest that these biomarkers may aid in timely intervention and the enhancement of outcomes for neonates affected by NEC.