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Abstract：
Interleukin (IL)-41 is a novel immunomodulatory cytokine involved in the pathogenesis of several inflammatory and metabolic illnesses. However, it remains unclear how IL-41 contributes to the pathogenesis of chronic obstructive pulmonary disease (COPD). Therefore, the aim of the present study was to explore the correlation between the expression level of IL-41 and acute exacerbation of COPD (AECOPD). In total, 107 patients with COPD and 56 healthy controls were recruited from the First Affiliated Hospital of Ningbo University (Ningbo, China). Serum IL-41, IL-6, and matrix metalloproteinase-2 (MMP-2) levels were evaluated using enzyme-linked immunosorbent assay. Serum amyloid A (SAA) and C-reactive protein (CRP) levels were assessed in the hospital laboratory. The levels of IL-41 were higher in the AECOPD group than in the stable COPD (SCOPD) and control groups (P<0.0001). IL-6, SAA and CRP levels, the percentage of neutrophils, as well as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios were higher in the AECOPD group than those in the SCOPD and control groups. The smoking index was positively correlated with serum IL-41, CRP and SAA levels. The expression level of IL-41 was correlated with the number of acute exacerbations, severity of the exacerbations, and COPD assessment test scores in the AECOPD group. Examination of the receiver operating characteristic (ROC) curves showed that IL-41, especially when combined with other inflammatory factors, had a specific diagnostic value for AECOPD. According to the ROC curve analysis, the area under the curve (AUC) for IL-41 was 0.742 (P=0.051), and the AUC for IL-41 combined with other inflammatory factors was 0.925 (P=0.030). Increased serum IL-41 levels were associated with AECOPD and may play a role in the monitoring and evaluation of COPD.
摘要：
白细胞介素（IL）-41是一种新型的免疫调节细胞因子，参与几种炎症和代谢疾病的发病机理。然而,目前尚不清楚IL-41如何参与慢性阻塞性肺疾病(COPD)的发病机制.因此,本研究旨在探讨IL-41表达水平与COPD急性加重(AECOPD)的相关性.总的来说,从宁波大学第一附属医院（宁波，中国）。采用酶联免疫吸附试验检测血清IL-41、IL-6和基质金属蛋白酶-2(MMP-2)水平。在医院实验室评估血清淀粉样蛋白A（SAA）和C反应蛋白（CRP）水平。AECOPD组IL-41水平高于COPD稳定期组和对照组(P<0.0001)。IL-6、SAA和CRP水平,中性粒细胞的百分比，AECOPD组的中性粒细胞/淋巴细胞比率和血小板/淋巴细胞比率高于SCOPD组和对照组.吸烟指数与血清IL-41、CRP、SAA水平呈正相关。IL-41的表达水平与急性加重次数相关,恶化的严重程度，AECOPD组的COPD评估测试评分。受试者工作特征(ROC)曲线检查显示,IL-41,特别是与其他炎症因子结合时,对AECOPD有特定的诊断价值。根据ROC曲线分析,IL-41的曲线下面积（AUC）为0.742（P=0.051），IL-41联合其他炎症因子的AUC为0.925(P=0.030)。血清IL-41水平升高与AECOPD相关，可能在COPD的监测和评估中发挥作用。
