PDF(Pubmed)
Abstract：
Serum amyloid A (SAA) proteins are highly conserved lipoproteins that are notoriously involved in the acute phase response and systemic amyloidosis, but their biological functions are incompletely understood. Recent work has shown that SAA proteins can enter the brain by crossing the intact blood-brain barrier (BBB), and that they can impair BBB functions. Once in the central nervous system (CNS), SAA proteins can have both protective and harmful effects, which have important implications for CNS disease. In this review of the thematic series on SAA, we discuss the existing literature that relates SAA to neuroinflammation and CNS disease, and the possible roles of the BBB in these relations.
摘要：
血清淀粉样蛋白A（SAA）蛋白是高度保守的脂蛋白，众所周知，它与急性期反应和系统性淀粉样变性有关。但是它们的生物学功能还不完全清楚。最近的研究表明，SAA蛋白可以通过穿过完整的血脑屏障（BBB）进入大脑，并且它们会损害BBB功能。一旦进入中枢神经系统（CNS），SAA蛋白可以同时具有保护作用和有害作用，这对中枢神经系统疾病有重要意义。在对SAA主题系列的回顾中，我们讨论了将SAA与神经炎症和中枢神经系统疾病相关的现有文献，以及血脑屏障在这些关系中的可能作用。
