PDF(Pubmed)
Abstract：
In older horses, basal metabolic rate decreases, and plasma metabolite and hormone concentrations related to energy metabolism change. The occurrence of age-related diseases, which increases in old animals, may enhance inflammatory reactivity (inflammaging). Finding the appropriate treatment for inflammaging at an early stage may prevent various age-related diseases. Changes in metabolite and hormone concentrations and enzyme activities involved in energy metabolism in the plasma of clinically healthy riding horses of various ages were measured to identify biomarkers of inflammaging (persistent low-grade inflammation that occurs with aging). All horses were clinically healthy, and their body condition scores (BCSs) were 4 or 5 (9-point scale). Plasma triglyceride (TG), total cholesterol (T-Cho), blood urea nitrogen (BUN), insulin concentrations, malondialdehyde (MDA), and serum amyloid A (SAA) concentrations generally increased with age. Adiponectin concentrations, plasma superoxide dismutase (SOD), and leukocyte AMP-activated protein kinase (AMPK) activities decreased, while plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), and glutathione peroxidase (GPx) remained unchanged as horses aged. Although riding horses that partake in continuous exercise seems to be less likely to develop inflammaging, horses over 17 years of age tend to show proinflammatory signs with disordered lipid metabolism. In riding horses, SAA, in combination with other markers, may be a useful biomarker for inflammaging and dysregulated lipid metabolism in aging horses.
摘要：
在老马中，基础代谢率下降，和血浆代谢物和激素浓度有关的能量代谢变化。与年龄有关的疾病的发生，在老动物中增加，可能会增强炎症反应性（炎症）。在早期找到适当的治疗方法可以预防各种与年龄有关的疾病。测量了不同年龄的临床健康骑马的血浆中的代谢物和激素浓度的变化以及与能量代谢有关的酶活性，以鉴定炎症（随衰老而发生的持续低度炎症）的生物标志物。所有的马都是临床健康的,他们的身体状况评分（BCSs）为4或5（9分）。血浆甘油三酯（TG），总胆固醇（T-Cho），血尿素氮(BUN),胰岛素浓度，丙二醛（MDA），血清淀粉样蛋白A（SAA）浓度通常随年龄增长而增加。脂联素浓度,血浆超氧化物歧化酶（SOD），白细胞AMP活化蛋白激酶(AMPK)活性降低,而血浆天冬氨酸转氨酶（AST），丙氨酸氨基转移酶（ALT），随着马的年龄增长，谷胱甘肽过氧化物酶（GPx）保持不变。虽然参加连续运动的骑马似乎不太可能出现炎症，17岁以上的马往往表现出促炎症状，脂质代谢紊乱。骑马，SAA,结合其他标记，可能是衰老马中炎症和脂质代谢失调的有用生物标志物。
