背景:在大多数黄色指甲综合征(YNS)病例中,黄色指甲的经典三合会,淋巴水肿和呼吸道表现很少同时出现。因此,诊断延迟或经常漏诊。
方法:我们报告了一名62岁的YNS患者,表现为双侧胸膜,心包和腹膜积液,2个月后,发展为微小变异型肾病综合征。用维生素E治疗后,克拉霉素和泼尼松3个月,胸腔积液,心包和腹腔下降,而尿蛋白水平恢复到正常范围内。
结论:临床医生应考虑出现多发性浆液性积液和肾病综合征的患者发生YNS的可能性。
BACKGROUND: In most cases of yellow nail syndrome (YNS), the classic triad of yellow nails, lymphedema and respiratory manifestations rarely manifest simultaneously. Therefore, diagnosis is delayed or frequently missed.
METHODS: We report a 62-year-old YNS patient presenting with bilateral pleural, pericardial and peritoneal effusions who, 2 mo later, developed minimal-change nephrotic syndrome. After treatment with vitamin E, clarithromycin and prednisone for 3 mo, effusions in the chest, pericardium and abdominal cavity decreased while urine protein levels returned to within normal ranges.
CONCLUSIONS: Clinicians should consider the possibility of YNS for patients presenting with multiple serous effusions and nephrotic syndromes.