PDF(Pubmed)
Abstract：
Yellow nail syndrome is a rare condition occurring sporadically, with an extremely low prevalence rate. This syndrome classically presents with a triad of lower extremity edema, yellow nails, and mucosal issues such as pleural effusion and/or chronic sinusitis. Two out of the three features are deemed sufficient to diagnose a person with yellow nail syndrome. We present a rare case of yellow nail syndrome that began with chronic leg swelling and later progressed to the development of an asymptomatic pleural effusion and finally discoloration of nails. In our case, the patient did have a significant recent history of a total knee replacement with a titanium implant. Of note was the chronology of events including leg edema and asymptomatic pleural effusion which were present even before the titanium knee implant. The third feature of the hardening and yellow discoloration of the nails was found to have developed following the knee replacement. Interestingly, on further evaluation, he was found to have IgM deficiency.
摘要：
黄指甲综合征是一种罕见的疾病，偶尔发生，患病率极低。这种综合征典型地表现为下肢水肿的三联征，黄色指甲,和粘膜问题，如胸腔积液和/或慢性鼻窦炎。三个特征中的两个被认为足以诊断患有黄色指甲综合征的人。我们介绍了一种罕见的黄色指甲综合征，该综合征始于慢性腿部肿胀，后来发展为无症状的胸腔积液，最后是指甲变色。在我们的案例中,患者近期确实有钛植入物全膝关节置换术的重要病史.值得注意的是事件的时间顺序，包括腿部水肿和无症状的胸腔积液，甚至在钛膝盖植入物之前就已经存在。发现指甲硬化和黄色变色的第三个特征是在膝关节置换后发展起来的。有趣的是,关于进一步的评估，他被发现患有IgM缺乏症。
