目的:为了确定皮肤颜色在涉及基底细胞癌(BCC)鉴定和治疗的随机对照试验(RCT)中的报道率,在十大皮肤病学杂志上。
方法:对十大皮肤病学期刊中涉及BCC的RCT进行了系统评价,由影响因子决定,从成立到7月11日,2023年。如果他们审查了预防措施,检测,和BCC的治疗,直接参与的患者,并被分类为随机对照试验。如果方法或结果中的人口统计学数据包括以下任何一项,则将报告肤色(SOC)的研究分类为阳性:Fitzpatrick量表,种族,种族,肤色,或晒伤倾向。
结果:在确定的51项研究中,只有23篇文章在结果部分报告了与肤色有关的数据(45.1%);而28篇文章在文本中提到了肤色(54.9%).进行亚组分析,研究地点或发表年份无统计学意义.
结论:皮肤暗色会使诊断皮肤肿瘤变得更加困难,种族是否会影响对治疗的反应尚不清楚。在国际顶级皮肤病学期刊中,与基底细胞癌相关的RCT中,少于50%的人在其结果部分与研究参与者有关的人口统计学部分中包括肤色。亚组分析表明,在美国进行的研究报告皮肤颜色少于一半的时间(40%)。此外,在过去的40年中,报告没有统计学上的显著差异.需要进一步的研究来确定与BCC相关的RCTS中种族/肤色的低报告率是否会影响该组患者护理的诊断或治疗建议。
OBJECTIVE: To determine the rate skin color is reported in randomized controlled trials (RCTs) involving basal cell carcinoma (BCC) identification and treatment in the top ten dermatology journals.
METHODS: A systematic review was conducted of RCTs involving BCC among the top ten dermatology journals, determined by impact factor, from inception to July 11th, 2023. Studies were included if they reviewed the prevention, detection, and treatment of BCC, directly involved patients, and were classified as RCTs. Studies were classified as positive for reporting skin of color (SOC) if the demographic data in the methods or results included any of the following terms: Fitzpatrick scale, race, ethnicity, skin of color, or sunburn tendency.
RESULTS: Of the 51 studies identified, only 23 articles reported data pertaining to skin color within the results section (45.1%); whereas 28 articles mentioned skin color somewhere within the text (54.9%). Subgroup analysis was performed, and no statistical significance was found for study location or year of publication.
CONCLUSIONS: Dark skin color can make it more difficult to diagnose skin tumors and it is unknown if race affects response to treatment. Less than 50% of RCTs related to basal cell carcinoma in top international dermatology journals included skin color within the demographic portion of their results section pertaining to study participants. Subgroup analysis demonstrated that studies performed within the United States reported skin color less than half the time (40%). Additionally, there has been no statistically significant difference in reporting over the past 4 decades. Further research is necessary to determine whether low reporting rates of race/skin color in BCC-related RCTS could impact diagnostic or treatment recommendations for patient care in this group.