背景:寻常痤疮是一种常见于有色人种患者皮肤的皮肤病。研究表明,氨苯砜凝胶,7.5%(Aczone)每天使用一次有效,安全,并且对男性和女性痤疮的治疗具有良好的耐受性。然而,在肤色人群中可用的数据最少。这个单一中心,开放标签的临床研究调查了氨苯砜凝胶的疗效和安全性,7.5%用于治疗Fitzpatrick皮肤IV-VI型患者的中度至重度寻常痤疮。
方法:本研究纳入二十(20)名患有中度至重度痤疮和Fitzpatrick皮肤类型IV-VI的成人受试者,并使用氨苯砜凝胶治疗,7.5%,每日一次,持续24周。
结果:氨苯砜凝胶,每天施用7.5%,持续24周,减少痤疮严重程度,炎症后色素沉着过度,和减少新的炎症和非炎性痤疮病变的颜色患者的皮肤中度至重度寻常痤疮。治疗改善了痤疮健康相关的生活质量和与痤疮相关的患者症状,包括患者报告的炎症后色素沉着过度,特别是治疗时间为18周或更长。局限性:样本量较小,检测某些终点的统计学显著变化的能力不足。
结论:氨苯砜凝胶7.5%是安全的,耐受性良好,并有效治疗皮肤色素沉着患者的寻常痤疮和炎症后色素沉着。有必要进行涉及寻常痤疮的肤色人群的较大研究。J药物Dermatol.2024;23(6):410–417。doi:10.36849/JDD.7897.
BACKGROUND: Acne vulgaris is a common skin disease prevalent in skin of color patients. Studies have demonstrated that dapsone gel, 7.5% (Aczone) used once daily is effective, safe, and well-tolerated for the treatment of acne in both men and women. However, minimal data are available in skin of color populations. This single-center, open-label clinical
study investigated the efficacy and safety of dapsone gel, 7.5% in the treatment of moderate to severe acne vulgaris in patients with Fitzpatrick skin types IV-VI.
METHODS: Twenty (20) adult subjects with moderate to severe acne and Fitzpatrick skin types IV-VI were enrolled in this
study and treated with dapsone gel, 7.5% once daily for 24 weeks.
RESULTS: Dapsone gel, 7.5% applied daily for 24 weeks reduced acne severity, post-inflammatory hyperpigmentation, and decreased new inflammatory and noninflammatory acne lesions in skin of color patients with moderate to severe acne vulgaris. Treatment resulted in improved acne health-related quality of life and patient symptoms related to acne, including patient-reported post-inflammatory hyperpigmentation, especially with a treatment duration of 18 weeks or longer. Limitations: The sample size was small and underpowered to detect statistically significant changes in some endpoints.
CONCLUSIONS: Dapsone gel 7.5% was safe, well-tolerated, and efficacious in treating acne vulgaris and post-inflammatory hyperpigmentation in skin-of-color patients. Larger studies involving skin-of-color populations with acne vulgaris are warranted. J Drugs Dermatol. 2024;23(6):410-417. doi:10.36849/JDD.7897.