PDF(Pubmed)
Abstract：
The skin-brain axis has been suggested to play a role in several pathophysiological conditions, including opioid addiction, Parkinson\'s disease and many others. Recent evidence suggests that pathways regulating skin pigmentation may directly and indirectly regulate behaviour. Conversely, CNS-driven neural and hormonal responses have been demonstrated to regulate pigmentation, e.g., under stress. Additionally, due to the shared neuroectodermal origins of the melanocytes and neurons in the CNS, certain CNS diseases may be linked to pigmentation-related changes due to common regulators, e.g., MC1R variations. Furthermore, the HPA analogue of the skin connects skin pigmentation to the endocrine system, thereby allowing the skin to index possible hormonal abnormalities visibly. In this review, insight is provided into skin pigment production and neuromelanin synthesis in the brain and recent findings are summarised on how signalling pathways in the skin, with a particular focus on pigmentation, are interconnected with the central nervous system. Thus, this review may supply a better understanding of the mechanism of several skin-brain associations in health and disease.
摘要：
皮肤-脑轴已被认为在几种病理生理状况中起作用，包括阿片类药物成瘾，帕金森病和许多其他疾病。最近的证据表明，调节皮肤色素沉着的途径可能直接和间接地调节行为。相反，中枢神经系统驱动的神经和激素反应已被证明可以调节色素沉着，例如，在压力下。此外,由于中枢神经系统中黑素细胞和神经元的共同神经外胚层起源，某些中枢神经系统疾病可能与色素沉着相关的变化有关，例如，MC1R变体。此外，皮肤的HPA类似物将皮肤色素沉着与内分泌系统联系起来，从而允许皮肤索引可能的荷尔蒙异常明显。在这次审查中,提供了对大脑中皮肤色素产生和神经黑色素合成的洞察力，并总结了最近的发现，特别关注色素沉着，与中枢神经系统相连。因此，这篇综述可能有助于更好地理解几种皮肤-大脑关联在健康和疾病中的作用机制.
