Whipple病(WD)是由Tropherymawhipplei引起的,常见于小肠固有层巨噬细胞。这是一种罕见的慢性全身性感染,主要临床表现是腹泻,减肥,腹痛,和关节痛.诊断困难主要是因为它的稀有性,应该在关节痛患者中考虑,腹泻,腹痛,和体重减轻后,更常见的情况已被排除。实验室诊断是通过十二指肠活检建立的。治疗涉及14天的静脉注射抗生素,在脑脊液中具有良好的渗透性(即,头孢曲松)和口服复方新诺明治疗一年。早期诊断和正确治疗至关重要,因为它可以改善预后。我们报道了一个58岁女性皮肤色素沉着过度的案例,食欲和体重下降(三个月内体重的16%),恶心,上腹痛,和腹泻。进行食管胃十二指肠镜检查和结肠镜检查以获取活检样本,which,连同实验室测试和微生物学研究,导致了惠普尔病的诊断。
Whipple\'s disease (WD) is caused by Tropheryma whipplei, frequently found in lamina propria\'s macrophages in the small intestine. It is a rare and chronic systemic infection, and the principal clinical manifestations are diarrhea, weight loss, abdominal pain, and arthralgia. The diagnosis is difficult mainly because of its rarity and should be considered in patients with arthralgias, diarrhea, abdominal pain, and weight loss after more common conditions have been excluded. The laboratory diagnosis is established by a duodenal biopsy. The treatment involves 14 days of intravenous antibiotics with good penetration in the cerebrospinal fluid (i.e., ceftriaxone) and one-year treatment with oral co-trimoxazole. Early diagnosis and proper treatment are crucial because it improves the prognosis. We report the
case of a 58-year-old female with skin hyperpigmentation, loss of appetite and weight (16% of body weight in three months), nausea, upper abdominal pain, and diarrhea. Esophagogastroduodenoscopy and colonoscopy were performed to obtain biopsy samples, which, together with laboratory tests and microbiological studies, led to a diagnosis of Whipple\'s disease.