背景:胰岛素对血糖控制有至关重要的影响,细胞生长,函数,和新陈代谢。它部分由营养素调节,尤其是对食物摄入的反应,包括碳水化合物.此外,当胰岛素插入大脑的下丘脑时,可以产生厌食作用,其中出现了一个复杂的食欲/饥饿控制系统网络。当前的文献综述旨在彻底总结和审查与长期使用蔗糖替代品(SS)相比,响应于葡萄糖暴露的胰岛素释放是否可能是控制体重增加和相关疾病的更好选择。均衡饮食。
方法:这是一个全面的文献综述,这是通过深入搜索最准确的科学数据库并应用有效和相关的关键词来执行的。
结果:胰岛素作用可以插入下丘脑促食欲/促食欲复合系统,激活几种食欲减退肽,增加食物摄入的享乐方面,有效控制人体体重。相比之下,SSs似乎不会影响食欲/厌食复杂系统,导致更多的病例不受控制的体重维持,同时也增加了发展相关疾病的风险。
结论:大多数证据,主要来自体外和体内动物研究,增强了大脑下丘脑的胰岛素促食欲作用。同时,大多数可用的临床研究表明,在均衡饮食期间,SSs可以保持甚至增加体重,这可能间接归因于它们不能涵盖食物摄入的享乐方面。然而,强烈需要长期纵向调查,以有效确定SS对人体代谢健康的影响.
BACKGROUND: Insulin exerts a crucial impact on glucose control, cellular growing, function, and metabolism. It is partially modulated by nutrients, especially as a response to the intake of foods, including carbohydrates. Moreover, insulin can exert an anorexigenic effect when inserted into the hypothalamus of the brain, in which a complex network of an appetite/hunger control system occurs. The current literature review aims at thoroughly summarizing and scrutinizing whether insulin release in response to glucose exposure may be a better choice to control body weight gain and related diseases compared to the use of sucrose substitutes (SSs) in combination with a long-term, well-balanced diet.
METHODS: This is a comprehensive literature review, which was performed through searching in-depth for the most accurate scientific databases and applying effective and relevant keywords.
RESULTS: The insulin action can be inserted into the hypothalamic orexigenic/anorexigenic complex system, activating several anorexigenic peptides, increasing the hedonic aspect of food intake, and effectively controlling the human body weight. In contrast, SSs appear not to affect the orexigenic/anorexigenic complex system, resulting in more cases of uncontrolled body weight maintenance while also increasing the risk of developing related diseases.
CONCLUSIONS: Most evidence, mainly derived from in vitro and in vivo animal studies, has reinforced the insulin anorexigenic action in the hypothalamus of the brain. Simultaneously, most available clinical studies showed that SSs during a well-balanced diet either maintain or even increase body weight, which may indirectly be ascribed to the fact that they cannot cover the hedonic aspect of food intake. However, there is a strong demand for long-term longitudinal surveys to effectively specify the impact of SSs on human metabolic health.