PDF(Pubmed)
Abstract：
Terminating a meal after achieving satiation is a critical step in maintaining a healthy energy balance. Despite the extensive collection of information over the last few decades regarding the neural mechanisms controlling overall eating, the mechanism underlying different temporal phases of eating behaviors, especially satiation, remains incompletely understood and is typically embedded in studies that measure the total amount of food intake. In this review, we summarize the neural circuits that detect and integrate satiation signals to suppress appetite, from interoceptive sensory inputs to the final motor outputs. Due to the well-established role of cholecystokinin (CCK) in regulating the satiation, we focus on the neural circuits that are involved in regulating the satiation effect caused by CCK. We also discuss several general principles of how these neural circuits control satiation, as well as the limitations of our current understanding of the circuits function. With the application of new techniques involving sophisticated cell-type-specific manipulation and mapping, as well as real-time recordings, it is now possible to gain a better understanding of the mechanisms specifically underlying satiation.
摘要：
在达到饱腹状态后终止一餐是维持健康能量平衡的关键步骤。尽管在过去的几十年中收集了大量关于控制整体饮食的神经机制的信息，饮食行为不同时间阶段的潜在机制，尤其是饱腹感，仍然不完全了解，通常被嵌入在测量食物摄入总量的研究中。在这次审查中,我们总结了检测和整合饱腹信号以抑制食欲的神经回路，从相互感受的感觉输入到最终的电机输出。由于胆囊收缩素（CCK）在调节饱腹感方面的作用，我们专注于参与调节CCK引起的饱腹效应的神经回路。我们还讨论了这些神经回路如何控制饱腹感的几个一般原则，以及我们目前对电路功能理解的局限性。随着涉及复杂的细胞类型特异性操作和映射的新技术的应用，以及实时记录，现在有可能更好地了解饱腹感的具体机制。
