PDF(Pubmed)
Abstract：
Scientists were chasing an incretin hormone, and when GLP-1 was finally discovered, we found that it had a pronounced satiety effect, slowed down gastric emptying, and actually reduced postprandial insulin response. These mechanisms are the basis for the highly efficacious GLP-1 analogues that today offer safe and effective treatment in millions of people living with obesity. Moreover, the combined GLP-1 mechanisms of weight loss and delayed carbohydrate absorption may also be the key drivers of remission of type 2 diabetes and reduced cardiovascular events found by GLP-1 analogues.
摘要：
科学家们正在追逐一种肠促胰岛素激素，当GLP-1最终被发现时，我们发现它有明显的饱腹感，减缓胃排空，实际上降低了餐后胰岛素反应。这些机制是高效GLP-1类似物的基础，目前在数百万肥胖患者中提供安全有效的治疗。此外，GLP-1体重减轻和碳水化合物吸收延迟的联合机制也可能是GLP-1类似物发现的2型糖尿病缓解和心血管事件减少的关键驱动因素.
