背景:多发性原发性黑色素瘤(MPM)是一种诊断挑战,即使是皮肤科医生可用的辅助成像技术。在选定的患者中,表型,成像方法的使用可以帮助更好地了解病变特征,并有助于早期诊断和管理。
方法:在为期5年的前瞻性单中心随访中,在两名一级亲属中诊断出58例原发性黑色素瘤(SPM),肤色白皙,红头发,绿色的眼睛,和以前的黑色素瘤的个人病史。从病历中收集患者的行为和描述性人口统计学数据。从病理报告中检索了前两个原发性黑色素瘤(PM)的信息。从病历中收集了60例黑色素瘤的特征,视频皮肤镜软件,和病理报告。在切除22个随机选择的黑色素瘤之前进行反射共聚焦显微镜(RCM)。
结果:从2018年2月到2023年5月,两名患者接受了总共214次可疑病变的切除活检,导致良性与恶性联合治疗比率(NNT)为2.0:1.0。对于女性和男性患者,每个诊断的黑素瘤(NNE)切除的摩尔数分别为1.7:1.0和6.9:1.0。原位黑素瘤/侵袭性黑素瘤比率(IIR)显示两名患者的原位黑素瘤比例更高。从2018年6月到2023年5月,通过全身皮肤联合检查(TBSE)共检测到58个SPM,全身皮肤摄影(TBSP),数字皮肤镜(DD),和通过比较方法进行序贯数字皮肤镜成像(SDDI)。较年轻的患者在第二次和第三次皮肤黑素瘤(CM)发生前一个月有PM,表征同步主CM的情况。男性年长的亲戚共有7例非同步性黑素瘤。
结论:该CM队列由83.3%的原位黑色素瘤和16.7%的侵袭性黑色素瘤组成。两组患者均有较高比例的SPM与临床痣样形态(84.5%),不对称多成分的整体皮肤模式(60.3%)和位于下肢(46.6%)。当在切除前进行RCM时,81%的SPM具有提示恶性肿瘤的特征。同样,侵袭性黑素瘤在下肢更为常见(40%)。在多变量模型中,对于研究的两名高危患者,与痣无关(“denovo”)侵入性SPM诊断的机会比与痣相关的侵入性SPM诊断的机会大25倍.
BACKGROUND: Multiple primary melanoma (MPM) is a diagnostic challenge even with ancillary imaging technologies available to dermatologists. In selected patients\' phenotypes, the use of imaging approaches can help better understand lesion characteristics, and aid in early diagnosis and management.
METHODS: Under a 5-year prospective single-center follow-up, 58 s primary melanomas (SPMs) were diagnosed in two first-degree relatives, with fair skin color, red hair, green eyes, and personal history of one previous melanoma each. Patients\' behavior and descriptive demographic data were collected from medical records. The information on the first two primary melanomas (PMs) were retrieved from pathology reports. The characteristics of 60 melanomas were collected from medical records, video dermoscopy software, and pathology reports. Reflectance confocal microscopy (RCM) was performed prior to excision of 22 randomly selected melanomas.
RESULTS: From February 2018 to May 2023, two patients underwent a pooled total of 214 excisional biopsies of suspect lesions, resulting in a combined benign versus malignant treatment ratio (NNT) of 2.0:1.0. The number of moles excised for each melanoma diagnosed (NNE) was 1.7:1.0 and 6.9:1.0 for the female and male patient respectively. The in-situ melanoma/invasive melanoma ratio (IIR) demonstrated a higher proportion of in-situ melanomas for both patients. From June 2018 to May 2023, a total of 58 SPMs were detected by the combination of total body skin exam (TBSE), total body skin photography (TBSP), digital dermoscopy (DD), and sequential digital dermoscopy imaging (SDDI) via comparative approach. The younger patient had her PM one month prior to the second and third cutaneous melanomas (CMs), characterizing a case of synchronous primary CM. The male older relative had a total of 7 nonsynchronous melanomas.
CONCLUSIONS: This CM cohort is composed of 83.3% in-situ melanoma and 16.7% invasive melanoma. Both patients had a higher percentage of SPM with clinical nevus-like morphology (84.5%), global dermoscopic pattern of asymmetric multiple component (60.3%) and located on the lower limbs (46.6%). When RCM was performed prior to excision, 81% of SPM had features suggestive of malignancy. As well, invasive melanomas were more frequent in the lower limbs (40%). In the multivariate model, for the two high-risk patients studied, the chance of a not associated with nevus (\"de novo\") invasive SPM diagnosis is 25 times greater than the chance of a diagnosis of a nevus-associated invasive SPM.