角质形成细胞癌的风险由内在和外在因素决定。这也会影响皮肤老化。很少有研究将皮肤老化和紫外线暴露与非黑色素瘤皮肤癌(NMSC)的发病率联系起来。我们评估了光化性皮肤损伤和老化的迹象,个人紫外线负担,和黑皮质素-1受体(MC1R)变体。总共194名患有NMSC的器官移植受者(OTR)与194名性别匹配的无肿瘤对照进行了比较。年龄,移植器官的类型,移植后(TX)期,和免疫抑制疗法.与案例相比,对照组在所有皮肤老化评分中得分较高,除了针对特定紫外线情况和生命时期的有意全身紫外线暴露外,紫外线负担没有差异。NMSCs的数量与所有类型的皮肤老化评分相关,故意暴露在阳光下的程度,年龄较大,更长的TX后周期,从TX到第一个NMSC的较短间隔,和特定的MC1R风险组。多变量模型显示光化性角化病个体发展NMSC的风险为7.5倍;绿色或蓝色眼睛的个体为4.1倍或3.6倍,MC1R中+高危人群的风险分别增加1.9倍。在没有皮肤老化促进NMSC发育的情况下,某些MC1R风险类型可确定OTR有高肿瘤负荷风险.
The risk of keratinocyte cancer is determined by intrinsic and extrinsic factors, which also influence skin aging. Few studies have linked skin aging and UV exposure with the incidence of non-melanoma skin cancer (NMSC). We evaluated signs of actinic skin damage and aging, individual UV burden, and melanocortin-1 receptor (
MC1R) variants. A total of 194 organ transplant recipients (OTR) who suffered from NMSC were compared to 194 tumor-free controls matched for gender, age, type of transplanted organ, post-transplantation (TX) period, and immunosuppressive therapy. Compared with the cases, the controls scored higher in all skin aging scores and there were no differences in UV burden except for intentional whole-body UV exposure for specific UV scenarios and periods of life in favor of cases. The number of NMSCs correlated with all types of skin aging scores, the extent of intentional sun exposure, older age, longer post-TX period, shorter interval from TX to first NMSC, and specific
MC1R risk groups. Multivariable models revealed a 7.5-fold risk of developing NMSC in individuals with actinic keratosis; 4.1- or 3.6-fold in those with green or blue eyes, respectively; and a 1.9-fold increased risk in the
MC1R medium- + high-risk group. In the absence of skin aging contributing to NMSC development, certain
MC1R risk types may identify OTR at risk for high tumor burden.