PDF(Pubmed)
Abstract：
Red hair has been linked to altered sensitivity to pain, analgesics, and hypnotics. This alteration may be impacted by variants in the melanocortin-1 receptor (MC1R) gene, which are mainly found in redheads. The aim of this narrative review was to explore and present the current state of knowledge on red hair and its plausible associations with altered responsiveness to pain, analgesics, and hypnotics. Structured searches in the PubMed, CINAHL Complete, and Scopus electronic databases were conducted. Evidence suggests that women with red hair have an increased sensitivity to pain. Conversely, data also indicate a higher pain tolerance in homozygous carriers of MC1R variant alleles. Varied responses to analgesia have been reported, with both increased analgesic responsiveness in homozygous carriers of MC1R variant alleles and less analgesia in redheads. Data indicate an increased need for hypnotics in redheads. However, failed attempts to find statistical associations between red hair and altered responsiveness to hypnotics are also evident. Even though there seems to be an association between red hair and an altered responsiveness to pain, analgesics, and/or hypnotics, the results of this narrative review are inconclusive. Further research studies with larger populations and MC1R testing are needed.
摘要：
红头发与对疼痛的敏感性改变有关，镇痛药,和催眠。这种改变可能受到黑皮质素-1受体（MC1R）基因变体的影响，主要见于红头发。这篇叙述性综述的目的是探索和呈现关于红头发的知识现状及其与疼痛反应性改变的合理关联，镇痛药,和催眠。PubMed中的结构化搜索，CINAHL完成,和Scopus电子数据库进行。有证据表明，红头发的女性对疼痛的敏感性增加。相反，数据还表明MC1R变体等位基因的纯合携带者具有较高的疼痛耐受性。已经报道了不同的镇痛反应，MC1R变异等位基因纯合携带者的镇痛反应性增加，而红发患者的镇痛作用减少。数据表明红头发对催眠药的需求增加。然而,发现红头发与催眠药反应性改变之间的统计关联的尝试失败也很明显.即使红头发和对疼痛的反应性改变之间似乎存在关联，镇痛药,和/或催眠药，这篇叙述性综述的结果尚无定论。需要对更大的人群和MC1R测试进行进一步的研究。
