人乳头瘤病毒(HPV)感染是目前女性宫颈癌及癌前病变的主要病因。通过分析中国上海周浦医院6年的患者数据,我们对女性的流行病学特征进行回顾性分析,以确定HPV基因型与细胞学检测结果之间的关系.
2014-2019年,上海周浦医院收集宫颈脱落病例23724例,中国。通过比较HPV和ThinPrep细胞学检查(TCT)的结果,回顾性分析患者HPV感染率。使用商业试剂盒进行HPV基因分型可以检测21种HPV亚型(15种高风险和6种低风险)。根据贝塞斯达系统的定义,涉及7种类型的宫颈细胞学结果.
23,724名女性中的3816名,近16.08%,感染了HPV。HPV感染率最高的前三位是高危型感染,包括HPV52(3.19%),58(2.47%)和16(2.34%)。单一类型HPV感染的数量(3480(91.20%))远大于多类型HPV感染的数量(336(8.8%))。单型感染主要发生在50-60岁女性(16.63%)和30岁以下女性(15.37%),而多型感染在60岁以上的女性中更为常见(2.67%)。通过分析长期趋势,2014年至2019年,HPV52、58和16亚型发生了显著变化,在此期间,HPV阳性率也发生了显着变化。在4502名TCT阳性女性中,15(4.04%),125(2.64%),159(1.54%),4202(17.71%)和1(0.004%)有非典型腺细胞(AGC),高级别鳞状上皮内病变(HSIL),低度鳞状上皮内病变(LSIL),非典型鳞状细胞(ASC)和宫颈腺癌,分别。HPV感染率为66.08%,63.99%,115.20%,119.50%,NILM为31.72%,AGC,HSILsLSILs和ASCs,分别。
HPV和TCT筛查是宫颈癌二级预防中非常重要的步骤。本研究通过对HPV和TCT结果的追踪分析,它可以为上海的HPV筛查和预防策略提供有价值的信息,为宫颈癌及癌前病变的临床治疗决策提供参考。
Human papillomavirus (HPV) infection is currently the main cause of cervical cancer and precancerous lesions in female patients. By analyzing 6-year patient data from Shanghai Zhoupu Hospital in China, we retrospectively analyzed the epidemiological characteristics of women to determine the relationship between HPV genotype and cytological test results.
From 2014 to 2019, 23,724 cases of cervical shedding were collected from Zhoupu Hospital in Shanghai, China. By comparing the results of HPV and ThinPrep cytology test (TCT), the HPV infection rate of patients was retrospectively analyzed. HPV genotyping using commercial kits can detect 21 HPV subtypes (15 high-risk and 6 low-risk). According to the definition of the Bethesda system, seven types of cervical cytology results were involved.
3816 among 23,724 women, nearly 16.08%, were infected with HPV. The top three highest HPV prevalence rates were high-risk type infection, including HPV52 (3.19%), 58 (2.47%) and 16 (2.34%). The number of single-type HPV infections (3480 (91.20%)) was much larger than the number of multi-type ones (336 (8.8%)). Single-type infections were mainly in women aged 50-60 (16.63%) and women under 30 (15.37%), while multi-type infections were more common in women over 60 (2.67%). By analyzing the long-term trends, between 2014 and 2019, HPV52, 58, and 16 subtypes changed significantly, and the HPV positive rate also changed significantly during this period. Among 4502 TCT positive women, 15 (4.04%), 125 (2.64%),159 (1.54%), 4202 (17.71%) and 1 (0.004%) had atypical glandular cells (AGC), high-grade squamous intraepithelial lesions (HSIL), low-grade squamous intraepithelial lesions (LSIL), atypical squamous cells (ASC)and cervical adenocarcinoma, respectively. The HPV infection rates were 66.08%, 63.99%, 115.20%, 119.50%, and 31.72% for NILM, AGCs, HSILs LSILs and ASCs, respectively.
HPV and TCT screening were very important steps in the secondary prevention of cervical cancer. Through the tracking and analysis of HPV and TCT results in this study, it can provide valuable information for Shanghai\'s HPV screening and prevention strategies, and provide references for clinical decision-making in the treatment of cervical cancer and precancerous lesions.