PDF(Pubmed)
Abstract：
To optimize seasonal influenza control and prevention programs in regions with potentially complicated seasonal patterns. Descriptive epidemiology was used to analyze the etiology of influenza, and chi-square tests were used to compare the epidemic patterns among different influenza virus types and subtypes/lineages. From January 2010 to December 2019, a total of 63,626 ILI cases were reported in Chongqing and 14,136 (22.22%) were laboratory-confirmed influenza cases. The proportions of specimens positive for influenza A and influenza B were 13.32% (8,478/63,626) and 8.86% (5,639/63,626), respectively. The proportion of positive specimens for influenza A reached the highest in winter (23.33%), while the proportion of positive specimens for influenza B reached the highest in spring (11.88%). Children aged 5-14 years old had the highest proportion of positive specimens for influenza. The influenza virus types/subtypes positive was significantly different by seasons and age groups (P<.001), but not by gender (p = .436). The vaccine strains were matched to the circulating influenza virus strains in all other years except for 2018 (vaccine strain was B/Colorado/06/2017; circulating strain was B/Yamagata). The study showed significant variations in epidemic patterns, including seasonal epidemic period and age distributions, among different influenza types, subtypes/lineages in Chongqing. Influenza vaccines matched to the circulating influenza virus strain in nine of the ten years. To prevent and mitigate the influenza outbreaks in this area, high risk population, especially children aged 5-14 years, are encouraged to get vaccinated against influenza before the epidemic seasons.
摘要：
在具有潜在复杂季节性模式的地区优化季节性流感控制和预防计划。描述性流行病学用于分析流感的病因，和卡方检验用于比较不同流感病毒类型和亚型/谱系之间的流行模式。2010年1月至2019年12月，重庆市共报告63,626例ILI病例，实验室确诊流感病例14,136例（22.22%）。甲型和乙型流感阳性标本比例分别为13.32%(8,478/63,626)和8.86%(5,639/63,626),分别。甲型流感阳性标本的比例在冬季达到最高(23.33%),而乙型流感阳性标本的比例在春季最高(11.88%)。5-14岁儿童的流感阳性标本比例最高。流感病毒类型/亚型阳性的季节和年龄组差异显著(P<.001),但不是按性别（p=.436）。除2018年外，疫苗株与所有其他年份的流行流感病毒株匹配（疫苗株为B/Colorado/06/2017；流行株为B/Yamagata）。研究表明，流行模式存在显著差异，包括季节性流行期和年龄分布，在不同的流感类型中，重庆的亚型/谱系。在10年中的9年中，流感疫苗与流行的流感病毒株相匹配。为了预防和减轻该地区的流感爆发，高危人群,尤其是5-14岁的儿童，鼓励在流行季节之前接种流感疫苗。
